TY - JOUR
T1 - Uptake of prenatal genetic diagnosis and termination of pregnancy by Omani Muslim families at risk of genetic disorders
T2 - experience over a 9-year period
AU - Bruwer, Zandré
AU - Al Ubaidani, Salwa
AU - Al Kharusi, Khalsa
AU - Al Murshedi, Fathiya
AU - Al-Maawali, Almundher
AU - Al Sayegh, Abeer
AU - Al Kindy, Adila
AU - Al Riyami, Nihal
AU - Al Dughaishi, Tamima
AU - Al Salmani, Mouza
AU - Al Hashmi, Nadia
AU - Al Shehhi, Maryam
AU - Al Fahdi, Badriya
AU - Al Amri, Sumaya
AU - Al-Thihli, Khalid
N1 - Funding Information:
We would like to acknowledge Yusra Al Balushi, Amel Al Foori, and Saida Al Hinai for their efforts related to gathering data for the study.
Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2022/6
Y1 - 2022/6
N2 - Studies on the acceptance of prenatal diagnosis and termination of pregnancy for single gene disorders within Islamic societies in the Middle East are limited. A few have examined the attitudes toward pregnancy termination for fetal indications, but a dearth of published data exists on actual behavior and uptake. This study reports on all prenatal diagnosis requests for single gene disorders, from the Sultanate of Oman, over 9 years. A retrospective study was conducted during which the medical records of all women who performed prenatal diagnoses for single gene disorders were reviewed. A total of 148 invasive procedures were performed for 114 families. The total number of yearly requests for prenatal diagnosis increased exponentially from three in 2012 to 21 in 2020. Sixty-four different diagnoses were tested for with the majority being autosomal recessive in nature. Seventy-one percent (28/39) of cases where an affected pregnancy was identified were terminated. Fifty-two of the 114 women (45.6%) repeated prenatal diagnosis in a future pregnancy. Seventy-two couples (63%) were consanguineous parents related as second cousins or closer. The majority of tests performed were for couples from Muscat (27%), Albatinah (27%), and Alsharqiya (20.3%) governorates in Oman. The findings of this study provide evidence that prenatal diagnosis is an acceptable reproductive option to prevent the occurrence of genetic disorders that meet termination eligibility criteria as outlined by the Islamic Jurisprudence (Fiqh) Council Fatwa, among Omani Muslim couples.
AB - Studies on the acceptance of prenatal diagnosis and termination of pregnancy for single gene disorders within Islamic societies in the Middle East are limited. A few have examined the attitudes toward pregnancy termination for fetal indications, but a dearth of published data exists on actual behavior and uptake. This study reports on all prenatal diagnosis requests for single gene disorders, from the Sultanate of Oman, over 9 years. A retrospective study was conducted during which the medical records of all women who performed prenatal diagnoses for single gene disorders were reviewed. A total of 148 invasive procedures were performed for 114 families. The total number of yearly requests for prenatal diagnosis increased exponentially from three in 2012 to 21 in 2020. Sixty-four different diagnoses were tested for with the majority being autosomal recessive in nature. Seventy-one percent (28/39) of cases where an affected pregnancy was identified were terminated. Fifty-two of the 114 women (45.6%) repeated prenatal diagnosis in a future pregnancy. Seventy-two couples (63%) were consanguineous parents related as second cousins or closer. The majority of tests performed were for couples from Muscat (27%), Albatinah (27%), and Alsharqiya (20.3%) governorates in Oman. The findings of this study provide evidence that prenatal diagnosis is an acceptable reproductive option to prevent the occurrence of genetic disorders that meet termination eligibility criteria as outlined by the Islamic Jurisprudence (Fiqh) Council Fatwa, among Omani Muslim couples.
KW - Genetic disorders
KW - Muslim
KW - Oman
KW - Prenatal genetic diagnosis
KW - Termination of pregnancy
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UR - https://www.mendeley.com/catalogue/ac546961-f58d-31c4-bad7-6671ac287c0f/
U2 - 10.1007/s12687-022-00584-1
DO - 10.1007/s12687-022-00584-1
M3 - Article
C2 - 35179721
AN - SCOPUS:85124724934
SN - 1868-310X
VL - 13
SP - 303
EP - 311
JO - Journal of Community Genetics
JF - Journal of Community Genetics
IS - 3
ER -