Treatment of malabsorption vitamin D deficiency myopathy with intramuscular vitamin D

Saif Alyaarubi, Celia Rodd

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


A nearly 5 year-old boy presented with proximal muscle weakness, reduced muscle bulk, a positive Gower sign and Trendelenburg gait. He was known to have cholestatic liver disease. Investigations revealed markedly low serum total calcium, elevated alkaline phosphatase, very low serum 25-hydroxyvitamin D, and radiographs consistent with active rickets despite the ongoing administration of a water-soluble preparation of vitamin D. Only i.v. calcitriol acutely corrected the hypocalcemia, despite trying several oral preparations, suggesting that malabsorption secondary to chronic liver disease was the cause of his rickets. Intramuscular calciferol quickly corrected his muscle weakness and X-ray findings. Myopathy secondary to vitamin D deficiency is an uncommon diagnosis in children. Intermittent calciferol is an inexpensive and practical treatment for vitamin D deficiency, especially if associated with malabsorption.

Original languageEnglish
Pages (from-to)719-722
Number of pages4
JournalJournal of Pediatric Endocrinology and Metabolism
Issue number7
Publication statusPublished - Jul 2005
Externally publishedYes


  • Intramuscular calciferol
  • Malabsorption
  • Progressive familial intrahepatic cholestasis
  • Vitamin D deficiency

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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