Transforming growth factor-β2 polymorphism and systemic lupus erythematosus

Aliya Alansari, Ali Hajeer, Lee Suan Teh, Ardeshir Bayat, Anne Mysercough, Ahmet Gül, Murat Inanc, Jose Ordi-Ros, William Ollier*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Objective. To determine whether transforming growth factor-β2 (TGF-β2) gene polymorphism is associated with systemic lupus erythematosus (SLE) susceptibility. TGF-β is a multifunctional family of cytokines important in tissue repair, inflammation and immunoregulation. SLE is thought to be a T cell dependent autoimmune disorder with T cell dysfunction. Due to its known suppressive effects on interleukin 2 dependent T cell growth, TGF-β2 is considered to be a candidate SLE susceptibility gene. Furthermore, SLE has been linked with a region to which the TGF-β2 gene has been mapped. Methods. Association studies were performed in 3 case-control populations, from Spain, Turkey, and UK, using a TGF-β2 5′-untranslated region (5′-UTR) 4 base pair (bp) insertion polymorphism. Genotyping was performed using fluorescent labeled polymerase chain reaction product sizing. Results. No significant differences were detected in TGF-β2 5′-UTR polymorphism allele frequencies between SLE patients and matched controls in the 3 populations studied. Conclusion. The 4 bp insertion polymorphism within the TGF-β2 gene does not appear to be associated with SLE. However, this does not rule out the possible involvement of TGF-β2 in the disease pathogenesis.

Original languageEnglish
Pages (from-to)1189-1191
Number of pages3
JournalJournal of Rheumatology
Issue number6
Publication statusPublished - 2002
Externally publishedYes


  • Systemic lupus erythematosus
  • Transforming growth factor β2

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology


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