TY - JOUR
T1 - Transforming growth factor-β2 polymorphism and systemic lupus erythematosus
AU - Alansari, Aliya
AU - Hajeer, Ali
AU - Teh, Lee Suan
AU - Bayat, Ardeshir
AU - Mysercough, Anne
AU - Gül, Ahmet
AU - Inanc, Murat
AU - Ordi-Ros, Jose
AU - Ollier, William
PY - 2002
Y1 - 2002
N2 - Objective. To determine whether transforming growth factor-β2 (TGF-β2) gene polymorphism is associated with systemic lupus erythematosus (SLE) susceptibility. TGF-β is a multifunctional family of cytokines important in tissue repair, inflammation and immunoregulation. SLE is thought to be a T cell dependent autoimmune disorder with T cell dysfunction. Due to its known suppressive effects on interleukin 2 dependent T cell growth, TGF-β2 is considered to be a candidate SLE susceptibility gene. Furthermore, SLE has been linked with a region to which the TGF-β2 gene has been mapped. Methods. Association studies were performed in 3 case-control populations, from Spain, Turkey, and UK, using a TGF-β2 5′-untranslated region (5′-UTR) 4 base pair (bp) insertion polymorphism. Genotyping was performed using fluorescent labeled polymerase chain reaction product sizing. Results. No significant differences were detected in TGF-β2 5′-UTR polymorphism allele frequencies between SLE patients and matched controls in the 3 populations studied. Conclusion. The 4 bp insertion polymorphism within the TGF-β2 gene does not appear to be associated with SLE. However, this does not rule out the possible involvement of TGF-β2 in the disease pathogenesis.
AB - Objective. To determine whether transforming growth factor-β2 (TGF-β2) gene polymorphism is associated with systemic lupus erythematosus (SLE) susceptibility. TGF-β is a multifunctional family of cytokines important in tissue repair, inflammation and immunoregulation. SLE is thought to be a T cell dependent autoimmune disorder with T cell dysfunction. Due to its known suppressive effects on interleukin 2 dependent T cell growth, TGF-β2 is considered to be a candidate SLE susceptibility gene. Furthermore, SLE has been linked with a region to which the TGF-β2 gene has been mapped. Methods. Association studies were performed in 3 case-control populations, from Spain, Turkey, and UK, using a TGF-β2 5′-untranslated region (5′-UTR) 4 base pair (bp) insertion polymorphism. Genotyping was performed using fluorescent labeled polymerase chain reaction product sizing. Results. No significant differences were detected in TGF-β2 5′-UTR polymorphism allele frequencies between SLE patients and matched controls in the 3 populations studied. Conclusion. The 4 bp insertion polymorphism within the TGF-β2 gene does not appear to be associated with SLE. However, this does not rule out the possible involvement of TGF-β2 in the disease pathogenesis.
KW - Systemic lupus erythematosus
KW - Transforming growth factor β2
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M3 - Article
C2 - 12064833
AN - SCOPUS:0035990232
SN - 0315-162X
VL - 29
SP - 1189
EP - 1191
JO - Journal of Rheumatology
JF - Journal of Rheumatology
IS - 6
ER -