TY - JOUR
T1 - Synthesis of Silver Nanoparticles Using Camellia sinensis Leaf Extract
T2 - Promising Particles for the Treatment of Cancer and Diabetes
AU - Hosen, Md Eram
AU - Rahman, Md Ataur
AU - Rahman, Md Sojiur
AU - Akash, Shopnil
AU - Khalekuzzaman, Md
AU - Alsahli, Abdulaziz Abdullah
AU - Bourhia, Mohammed
AU - Nafidi, Hiba Allah
AU - Islam, Md Asadul
AU - Zaman, Rashed
N1 - Publisher Copyright:
© 2024 Wiley-VHCA AG, Zurich, Switzerland.
PY - 2024/2/15
Y1 - 2024/2/15
N2 - Both diabetes and cancer pose significant threats to public health. To overcome these challenges, nanobiotechnology offers innovative solutions for the treatment of these diseases. However, the synthesis of nanoparticles can be complex, costly and environmentally toxic. Therefore, in this study, we successfully synthesized Camellia sinensis silver nanoparticles (CS-AgNPs) biologically from methanolic leaf extract of C. sinensis and as confirmed by the visual appearance which exhibited strong absorption at 456 nm in UV-visible spectroscopy. The fourier transform infrared spectroscopy (FTIR) analysis revealed that phytochemicals of C. sinensis were coated with AgNPs. Scanning electron microscopy (SEM) analysis showed the spherical shape of CS-AgNPs, with a size of 15.954 nm, while X-ray diffraction spectrometry (XRD) analysis detected a size of 20.32 nm. Thermogravimetric analysis (TGA) indicated the thermal stability of CS-AgNPs. The synthesized CS-AgNPs significantly inhibited the ehrlich ascites carcinoma (EAC) cell growth with 53.42±1.101 %. The EAC cell line induced mice exhibited increased level of the serum aspartate aminotransferase (AST), alanine transaminase (ALT), and alkaline phosphatase (ALP), however this elevated serum parameter significantly reduced and controlled by the treatment with CS-AgNPs. Moreover, in a streptozotocin-induced diabetic mice model, CS-AgNPs greatly reduced blood glucose, total cholesterol, triglyceride, low-density lipoprotein (LDL) and creatinine levels. These findings highlight that the synthesized CS-AgNPs have significant anticancer and antidiabetic activities that could be used as promising particles for the treatment of these major diseases. However, pre-clinical and clinical trial should be addressed before use this particles as therapeutics agents.
AB - Both diabetes and cancer pose significant threats to public health. To overcome these challenges, nanobiotechnology offers innovative solutions for the treatment of these diseases. However, the synthesis of nanoparticles can be complex, costly and environmentally toxic. Therefore, in this study, we successfully synthesized Camellia sinensis silver nanoparticles (CS-AgNPs) biologically from methanolic leaf extract of C. sinensis and as confirmed by the visual appearance which exhibited strong absorption at 456 nm in UV-visible spectroscopy. The fourier transform infrared spectroscopy (FTIR) analysis revealed that phytochemicals of C. sinensis were coated with AgNPs. Scanning electron microscopy (SEM) analysis showed the spherical shape of CS-AgNPs, with a size of 15.954 nm, while X-ray diffraction spectrometry (XRD) analysis detected a size of 20.32 nm. Thermogravimetric analysis (TGA) indicated the thermal stability of CS-AgNPs. The synthesized CS-AgNPs significantly inhibited the ehrlich ascites carcinoma (EAC) cell growth with 53.42±1.101 %. The EAC cell line induced mice exhibited increased level of the serum aspartate aminotransferase (AST), alanine transaminase (ALT), and alkaline phosphatase (ALP), however this elevated serum parameter significantly reduced and controlled by the treatment with CS-AgNPs. Moreover, in a streptozotocin-induced diabetic mice model, CS-AgNPs greatly reduced blood glucose, total cholesterol, triglyceride, low-density lipoprotein (LDL) and creatinine levels. These findings highlight that the synthesized CS-AgNPs have significant anticancer and antidiabetic activities that could be used as promising particles for the treatment of these major diseases. However, pre-clinical and clinical trial should be addressed before use this particles as therapeutics agents.
KW - anticancer activity
KW - antidiabetic activity
KW - Camellia sinensis
KW - silver nanoparticles
KW - Camellia sinensis/metabolism
KW - Metal Nanoparticles/chemistry
KW - Diabetes Mellitus, Experimental/drug therapy
KW - Spectroscopy, Fourier Transform Infrared
KW - Neoplasms
KW - Silver/chemistry
KW - Anti-Bacterial Agents
KW - Animals
KW - X-Ray Diffraction
KW - Mice
KW - Plant Extracts/chemistry
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UR - http://www.scopus.com/inward/citedby.url?scp=85185133707&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/0a36e316-b9f1-3dcc-a76f-b5206f2cbd17/
U2 - 10.1002/cbdv.202301661
DO - 10.1002/cbdv.202301661
M3 - Article
C2 - 38359057
AN - SCOPUS:85185133707
SN - 1612-1872
VL - 21
JO - Chemistry and Biodiversity
JF - Chemistry and Biodiversity
IS - 3
M1 - e202301661
ER -