Synthesis and radiolabeling of new N-[(4-[18F]Fluorobenzylidene) aminooxy) alkyl]-2-nitroimidazoles as possible hypoxia imaging pharmaceuticals

Raid J. Abdel-Jalil; Marwa Aqarbeh; Dirk Löffler; Bin Shen; Sultan Abo Orabi; Wolfgang Voelter; Hans Jürgen MacHulla

doi:10.1007/s10967-009-0313-2

Synthesis and radiolabeling of new N-[(4-[¹⁸F]Fluorobenzylidene) aminooxy) alkyl]-2-nitroimidazoles as possible hypoxia imaging pharmaceuticals

Raid J. Abdel-Jalil, Marwa Aqarbeh, Dirk Löffler, Bin Shen, Sultan Abo Orabi, Wolfgang Voelter, Hans Jürgen MacHulla

Chemistry

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

The synthesis of the three ¹⁸F-labeled 2-nitroimidazoyl oximes is described to be used as possible hypoxia tumor imaging agents. The title oximes were successfully synthesized in a four step sequence, characterized, and finally radiolabeled. Under optimized labeling conditions, the radiochemical yields of the three markers were in the range of 69-80%.

Original language	English
Pages (from-to)	239-243
Number of pages	5
Journal	Journal of Radioanalytical and Nuclear Chemistry
Volume	283
Issue number	1
DOIs	https://doi.org/10.1007/s10967-009-0313-2
Publication status	Published - Jan 2010

Keywords

2-Nitroimidazole
Aminooxy
Hypoxia markers

ASJC Scopus subject areas

Analytical Chemistry
Nuclear Energy and Engineering
Radiology Nuclear Medicine and imaging
Pollution
Spectroscopy
Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

Access to Document

10.1007/s10967-009-0313-2

Cite this

@article{83945507b8224624aad0efec1faf7753,

title = "Synthesis and radiolabeling of new N-[(4-[18F]Fluorobenzylidene) aminooxy) alkyl]-2-nitroimidazoles as possible hypoxia imaging pharmaceuticals",

abstract = "The synthesis of the three 18F-labeled 2-nitroimidazoyl oximes is described to be used as possible hypoxia tumor imaging agents. The title oximes were successfully synthesized in a four step sequence, characterized, and finally radiolabeled. Under optimized labeling conditions, the radiochemical yields of the three markers were in the range of 69-80%.",

keywords = "2-Nitroimidazole, Aminooxy, Hypoxia markers",

author = "Abdel-Jalil, {Raid J.} and Marwa Aqarbeh and Dirk L{\"o}ffler and Bin Shen and Orabi, {Sultan Abo} and Wolfgang Voelter and MacHulla, {Hans J{\"u}rgen}",

note = "Funding Information: Acknowledgments Financial support, provided by the Hashemite University, is greatly acknowledged. R.A.-J thanks Deutsche Fors-chungsgemeinschaft (DFG) for a research visit fellowship. This work is part of a research project funded by Deutsche Forschungsgeme-inschaft (DFG), grant number PI 242/3-1.",

year = "2010",

month = jan,

doi = "10.1007/s10967-009-0313-2",

language = "English",

volume = "283",

pages = "239--243",

journal = "Journal of Radioanalytical and Nuclear Chemistry",

issn = "0236-5731",

publisher = "Springer Netherlands",

number = "1",

}

TY - JOUR

T1 - Synthesis and radiolabeling of new N-[(4-[18F]Fluorobenzylidene) aminooxy) alkyl]-2-nitroimidazoles as possible hypoxia imaging pharmaceuticals

AU - Abdel-Jalil, Raid J.

AU - Aqarbeh, Marwa

AU - Löffler, Dirk

AU - Shen, Bin

AU - Orabi, Sultan Abo

AU - Voelter, Wolfgang

AU - MacHulla, Hans Jürgen

N1 - Funding Information: Acknowledgments Financial support, provided by the Hashemite University, is greatly acknowledged. R.A.-J thanks Deutsche Fors-chungsgemeinschaft (DFG) for a research visit fellowship. This work is part of a research project funded by Deutsche Forschungsgeme-inschaft (DFG), grant number PI 242/3-1.

PY - 2010/1

Y1 - 2010/1

N2 - The synthesis of the three 18F-labeled 2-nitroimidazoyl oximes is described to be used as possible hypoxia tumor imaging agents. The title oximes were successfully synthesized in a four step sequence, characterized, and finally radiolabeled. Under optimized labeling conditions, the radiochemical yields of the three markers were in the range of 69-80%.

AB - The synthesis of the three 18F-labeled 2-nitroimidazoyl oximes is described to be used as possible hypoxia tumor imaging agents. The title oximes were successfully synthesized in a four step sequence, characterized, and finally radiolabeled. Under optimized labeling conditions, the radiochemical yields of the three markers were in the range of 69-80%.

KW - 2-Nitroimidazole

KW - Aminooxy

KW - Hypoxia markers

UR - http://www.scopus.com/inward/record.url?scp=77949266591&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77949266591&partnerID=8YFLogxK

U2 - 10.1007/s10967-009-0313-2

DO - 10.1007/s10967-009-0313-2

M3 - Article

AN - SCOPUS:77949266591

SN - 0236-5731

VL - 283

SP - 239

EP - 243

JO - Journal of Radioanalytical and Nuclear Chemistry

JF - Journal of Radioanalytical and Nuclear Chemistry

IS - 1

ER -