Synthesis and radiolabeling of new N-[(4-[18F]Fluorobenzylidene) aminooxy) alkyl]-2-nitroimidazoles as possible hypoxia imaging pharmaceuticals

Raid J. Abdel-Jalil; Marwa Aqarbeh; Dirk Löffler; Bin Shen; Sultan Abo Orabi; Wolfgang Voelter; Hans Jürgen MacHulla

doi:10.1007/s10967-009-0313-2

Synthesis and radiolabeling of new N-[(4-[¹⁸F]Fluorobenzylidene) aminooxy) alkyl]-2-nitroimidazoles as possible hypoxia imaging pharmaceuticals

Raid J. Abdel-Jalil, Marwa Aqarbeh, Dirk Löffler, Bin Shen, Sultan Abo Orabi, Wolfgang Voelter, Hans Jürgen MacHulla

نتاج البحث: المساهمة في مجلة › Article › مراجعة النظراء

8 اقتباسات (Scopus)

ملخص

The synthesis of the three ¹⁸F-labeled 2-nitroimidazoyl oximes is described to be used as possible hypoxia tumor imaging agents. The title oximes were successfully synthesized in a four step sequence, characterized, and finally radiolabeled. Under optimized labeling conditions, the radiochemical yields of the three markers were in the range of 69-80%.

اللغة الأصلية	English
الصفحات (من إلى)	239-243
عدد الصفحات	5
دورية	Journal of Radioanalytical and Nuclear Chemistry
مستوى الصوت	283
رقم الإصدار	1
المعرِّفات الرقمية للأشياء	https://doi.org/10.1007/s10967-009-0313-2
حالة النشر	Published - يناير 2010
منشور خارجيًا	نعم

ASJC Scopus subject areas

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أهداف الأمم المتحدة للتنمية المستدامة

يساهم هذا المخرج في تحقيق أهداف الأمم المتحدة للتنمية المستدامة التالية (SDGs)

الوصول إلى المستند

10.1007/s10967-009-0313-2

الملفات والروابط الأخرى

قم بذكر هذا

Synthesis and radiolabeling of new N-[(4-[¹⁸F]Fluorobenzylidene) aminooxy) alkyl]-2-nitroimidazoles as possible hypoxia imaging pharmaceuticals. / Abdel-Jalil, Raid J.; Aqarbeh, Marwa; Löffler, Dirk وآخرون.
في: Journal of Radioanalytical and Nuclear Chemistry, المجلد 283, رقم 1, ٠١.٢٠١٠, صفحة 239-243.

نتاج البحث: المساهمة في مجلة › Article › مراجعة النظراء

Abdel-Jalil, RJ, Aqarbeh, M, Löffler, D, Shen, B, Orabi, SA, Voelter, W & MacHulla, HJ 2010, 'Synthesis and radiolabeling of new N-[(4-[¹⁸F]Fluorobenzylidene) aminooxy) alkyl]-2-nitroimidazoles as possible hypoxia imaging pharmaceuticals', Journal of Radioanalytical and Nuclear Chemistry, المجلد 283, رقم 1, الصفحات 239-243. https://doi.org/10.1007/s10967-009-0313-2

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abstract = "The synthesis of the three 18F-labeled 2-nitroimidazoyl oximes is described to be used as possible hypoxia tumor imaging agents. The title oximes were successfully synthesized in a four step sequence, characterized, and finally radiolabeled. Under optimized labeling conditions, the radiochemical yields of the three markers were in the range of 69-80%.",

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note = "Funding Information: Acknowledgments Financial support, provided by the Hashemite University, is greatly acknowledged. R.A.-J thanks Deutsche Fors-chungsgemeinschaft (DFG) for a research visit fellowship. This work is part of a research project funded by Deutsche Forschungsgeme-inschaft (DFG), grant number PI 242/3-1.",

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AU - Shen, Bin

AU - Orabi, Sultan Abo

AU - Voelter, Wolfgang

AU - MacHulla, Hans Jürgen

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