TY - JOUR
T1 - Swim exercise inhibits hemostatic abnormalities in a rat model of obesity and insulin resistance
AU - Dallak, Mohammad
AU - Bin-Jaliah, Ismaeel
AU - Sakr, Hussein F.
AU - Al-Ani, Bahjat
AU - Haidara, Mohamed A.
N1 - Publisher Copyright:
© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Background: We sought to determine whether swim exercise can inhibit high carbohydrate and fat diet (HCFD)-induced biomarkers of coagulation and thrombosis. Material and methods: Rats were either fed with HCFD (model group) or a standard laboratory chow (control group) for 15 weeks. Swim exercise-‘treated’ rats started swim exercise training from the 11 th week until being sacrificed, on Week 15. Results: HCFD caused a significant increase in blood glucose, insulin resistance (HOMA-IR), lipidemia, and inflammatory biomarkers. In addition, HCFD significantly modulated coagulation and thrombosis biomarkers; fibrinogen, plasminogen activator inhibitor-1, von Willebrand factor, prothrombin time, activated partial thromboplastin time, blood clotting and bleeding time, and ADP-induced platelet aggregation that was effectively inhibited by swimming exercises. Conclusions: We demonstrate that in an animal model of obesity and insulin resistance, there is a significant change in hemostasis, which is ameliorated by swim exercise.
AB - Background: We sought to determine whether swim exercise can inhibit high carbohydrate and fat diet (HCFD)-induced biomarkers of coagulation and thrombosis. Material and methods: Rats were either fed with HCFD (model group) or a standard laboratory chow (control group) for 15 weeks. Swim exercise-‘treated’ rats started swim exercise training from the 11 th week until being sacrificed, on Week 15. Results: HCFD caused a significant increase in blood glucose, insulin resistance (HOMA-IR), lipidemia, and inflammatory biomarkers. In addition, HCFD significantly modulated coagulation and thrombosis biomarkers; fibrinogen, plasminogen activator inhibitor-1, von Willebrand factor, prothrombin time, activated partial thromboplastin time, blood clotting and bleeding time, and ADP-induced platelet aggregation that was effectively inhibited by swimming exercises. Conclusions: We demonstrate that in an animal model of obesity and insulin resistance, there is a significant change in hemostasis, which is ameliorated by swim exercise.
KW - Obesity
KW - coagulation
KW - exercise
KW - insulin resistance
KW - rat model
KW - thrombosis
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U2 - 10.1080/13813455.2018.1437749
DO - 10.1080/13813455.2018.1437749
M3 - Article
AN - SCOPUS:85041911719
SN - 1381-3455
VL - 125
SP - 79
EP - 84
JO - Archives of Physiology and Biochemistry
JF - Archives of Physiology and Biochemistry
IS - 1
ER -
