Swim exercise inhibits hemostatic abnormalities in a rat model of obesity and insulin resistance

Mohammad Dallak, Ismaeel Bin-Jaliah, Hussein F. Sakr, Bahjat Al-Ani, Mohamed A. Haidara*

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةArticleمراجعة النظراء

4 اقتباسات (Scopus)

ملخص

Background: We sought to determine whether swim exercise can inhibit high carbohydrate and fat diet (HCFD)-induced biomarkers of coagulation and thrombosis. Material and methods: Rats were either fed with HCFD (model group) or a standard laboratory chow (control group) for 15 weeks. Swim exercise-‘treated’ rats started swim exercise training from the 11th week until being sacrificed, on Week 15. Results: HCFD caused a significant increase in blood glucose, insulin resistance (HOMA-IR), lipidemia, and inflammatory biomarkers. In addition, HCFD significantly modulated coagulation and thrombosis biomarkers; fibrinogen, plasminogen activator inhibitor-1, von Willebrand factor, prothrombin time, activated partial thromboplastin time, blood clotting and bleeding time, and ADP-induced platelet aggregation that was effectively inhibited by swimming exercises. Conclusions: We demonstrate that in an animal model of obesity and insulin resistance, there is a significant change in hemostasis, which is ameliorated by swim exercise.

اللغة الأصليةEnglish
الصفحات (من إلى)1-6
عدد الصفحات6
دوريةArchives of Physiology and Biochemistry
المعرِّفات الرقمية للأشياء
حالة النشرAccepted/In press - فبراير 13 2018

ASJC Scopus subject areas

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  • ???subjectarea.asjc.2700.2737???

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