TY - JOUR
T1 - SOD2, a Potential Transcriptional Target Underpinning CD44-Promoted Breast Cancer Progression
AU - Alateyah, Nouralhuda
AU - Gupta, Ishita
AU - Rusyniak, Radoslaw Stefan
AU - Ouhtit, Allal
N1 - Funding Information:
This research was funded by Qatar University Internal grant number: QUST-1-CAS2019-22, QUST-2-CAS-2021-137 and QUST-2-CAS-2021-138 and, the Qatar Foundation grant number: UREP24-117-1-027. Open Access funding was provided by the Qatar National Library.
Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/1/26
Y1 - 2022/1/26
N2 - CD44, a cell-adhesion molecule has a dual role in tumor growth and progression; it acts as a tumor suppressor as well as a tumor promoter. In our previous work, we developed a tetracycline-off regulated expression of CD44’s gene in the breast cancer (BC) cell line MCF-7 (B5 clone). Using cDNA oligo gene expression microarray, we identified SOD2 (superoxide dismutase 2) as a potential CD44-downstream transcriptional target involved in BC metastasis. SOD2 gene belongs to the family of iron/manganese superoxide dismutase family and encodes a mitochondrial protein. SOD2 plays a role in cell proliferation and cell invasion via activation of different signaling pathways regulating angiogenic abilities of breast tumor cells. This review will focus on the findings supporting the underlying mechanisms associated with the oncogenic potential of SOD2 in the onset and progression of cancer, especially in BC and the potential clinical relevance of its various inhibitors.
AB - CD44, a cell-adhesion molecule has a dual role in tumor growth and progression; it acts as a tumor suppressor as well as a tumor promoter. In our previous work, we developed a tetracycline-off regulated expression of CD44’s gene in the breast cancer (BC) cell line MCF-7 (B5 clone). Using cDNA oligo gene expression microarray, we identified SOD2 (superoxide dismutase 2) as a potential CD44-downstream transcriptional target involved in BC metastasis. SOD2 gene belongs to the family of iron/manganese superoxide dismutase family and encodes a mitochondrial protein. SOD2 plays a role in cell proliferation and cell invasion via activation of different signaling pathways regulating angiogenic abilities of breast tumor cells. This review will focus on the findings supporting the underlying mechanisms associated with the oncogenic potential of SOD2 in the onset and progression of cancer, especially in BC and the potential clinical relevance of its various inhibitors.
KW - Breast cancer
KW - CD44
KW - Hyaluronan
KW - Invasion
KW - SOD2
KW - Hyaluronan Receptors/analysis
KW - Superoxide Dismutase/analysis
KW - Humans
KW - Transcriptional Activation
KW - Gene Expression Regulation, Neoplastic
KW - Disease Progression
KW - Neoplasm Invasiveness/genetics
KW - Animals
KW - Female
KW - Breast Neoplasms/genetics
UR - http://www.scopus.com/inward/record.url?scp=85123508438&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85123508438&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/2a2ee6de-5458-36cd-aa3f-eca18e48d035/
U2 - 10.3390/molecules27030811
DO - 10.3390/molecules27030811
M3 - Article
C2 - 35164076
AN - SCOPUS:85123508438
SN - 1420-3049
VL - 27
JO - Molecules
JF - Molecules
IS - 3
M1 - 811
ER -
