Potent bactericidal activity of silver nanoparticles synthesized from Cassia fistula fruit

Muhammad Imtiaz Rashid; Liyakat Hamid Mujawar; Mohammad Ibrahim Mujallid; Muhammad Shahid; Zulfiqar Ahmad Rehan; Muhammad Kashif Iqbal Khan; Iqbal M.I. Ismail

doi:10.1016/j.micpath.2017.03.048

Potent bactericidal activity of silver nanoparticles synthesized from Cassia fistula fruit

Muhammad Imtiaz Rashid^*, Liyakat Hamid Mujawar, Mohammad Ibrahim Mujallid, Muhammad Shahid, Zulfiqar Ahmad Rehan, Muhammad Kashif Iqbal Khan, Iqbal M.I. Ismail

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

We demonstrated one-step synthesis of silver nanoparticles (AgNPs) from Cassia fistula fruit extract and their antibacterial activity against E. coli and K. pneumoniae. Biogenic AgNPs were characterized by scanning electron microscopy, X-Ray diffraction and fourier transform infrared spectroscopy. Results confirmed spherical shaped AgNPs with an average crystallite size of ∼69 nm. Dose-dependent (0, 10, 20, 40 and 80 μg mL⁻¹) growth kinetic studies showed 100% potency against E. coli (20 μg mL⁻¹) and K. pneumoniae (80 μg mL⁻¹) after 1 and 5 h, respectively. Surface morphology analysis revealed formation of groove/pits in the lysed cell membrane that eventually led to bacterial death.

Original language	English
Pages (from-to)	354-360
Number of pages	7
Journal	Microbial Pathogenesis
Volume	107
DOIs	https://doi.org/10.1016/j.micpath.2017.03.048
Publication status	Published - Jun 1 2017

Keywords

Biogenic
Gram negative bacteria
MIC
Silver nanoparticles
X-ray techniques

ASJC Scopus subject areas

Microbiology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.micpath.2017.03.048

Cite this

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title = "Potent bactericidal activity of silver nanoparticles synthesized from Cassia fistula fruit",

abstract = "We demonstrated one-step synthesis of silver nanoparticles (AgNPs) from Cassia fistula fruit extract and their antibacterial activity against E. coli and K. pneumoniae. Biogenic AgNPs were characterized by scanning electron microscopy, X-Ray diffraction and fourier transform infrared spectroscopy. Results confirmed spherical shaped AgNPs with an average crystallite size of ∼69 nm. Dose-dependent (0, 10, 20, 40 and 80 μg mL−1) growth kinetic studies showed 100% potency against E. coli (20 μg mL−1) and K. pneumoniae (80 μg mL−1) after 1 and 5 h, respectively. Surface morphology analysis revealed formation of groove/pits in the lysed cell membrane that eventually led to bacterial death.",

keywords = "Biogenic, Gram negative bacteria, MIC, Silver nanoparticles, X-ray techniques",

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AU - Rashid, Muhammad Imtiaz

AU - Mujawar, Liyakat Hamid

AU - Mujallid, Mohammad Ibrahim

AU - Shahid, Muhammad

AU - Rehan, Zulfiqar Ahmad

AU - Khan, Muhammad Kashif Iqbal

AU - Ismail, Iqbal M.I.

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AB - We demonstrated one-step synthesis of silver nanoparticles (AgNPs) from Cassia fistula fruit extract and their antibacterial activity against E. coli and K. pneumoniae. Biogenic AgNPs were characterized by scanning electron microscopy, X-Ray diffraction and fourier transform infrared spectroscopy. Results confirmed spherical shaped AgNPs with an average crystallite size of ∼69 nm. Dose-dependent (0, 10, 20, 40 and 80 μg mL−1) growth kinetic studies showed 100% potency against E. coli (20 μg mL−1) and K. pneumoniae (80 μg mL−1) after 1 and 5 h, respectively. Surface morphology analysis revealed formation of groove/pits in the lysed cell membrane that eventually led to bacterial death.

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KW - Gram negative bacteria

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KW - Silver nanoparticles

KW - X-ray techniques

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