Lipopeptidomimetics derived from teixobactin have potent antibacterial activity against: Staphylococcus aureus

Georgina C. Girt; Amit Mahindra; Zaaima J.H. Al Jabri; Megan De Ste Croix; Marco R. Oggioni; Andrew G. Jamieson

doi:10.1039/c7cc06093a

Lipopeptidomimetics derived from teixobactin have potent antibacterial activity against: Staphylococcus aureus

Georgina C. Girt, Amit Mahindra, Zaaima J.H. Al Jabri, Megan De Ste Croix, Marco R. Oggioni, Andrew G. Jamieson^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

A series of lipopeptidomimetics derived from teixobactin have been prepared that probe the role of residues (1-6) as a membrane anchor and the function of enduracididine. The most active compounds, with a farnesyl tail and End10 to Lys10 or Orn10 substitution have potent activity (MIC 8 μg mL^-1) against S. aureus. These results pave the way for the synthesis of simple, cost-effective yet potent lipopeptidomimetic antimicrobials.

Original language	English
Pages (from-to)	2767-2770
Number of pages	4
Journal	Chemical Communications
Volume	54
Issue number	22
DOIs	https://doi.org/10.1039/c7cc06093a
Publication status	Published - 2018
Externally published	Yes

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Ceramics and Composites
Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
General Chemistry
Catalysis

Access to Document

10.1039/c7cc06093a

Cite this

@article{1ed7a380e90a4bd09deffe7c73d3f0c0,

title = "Lipopeptidomimetics derived from teixobactin have potent antibacterial activity against: Staphylococcus aureus",

abstract = "A series of lipopeptidomimetics derived from teixobactin have been prepared that probe the role of residues (1-6) as a membrane anchor and the function of enduracididine. The most active compounds, with a farnesyl tail and End10 to Lys10 or Orn10 substitution have potent activity (MIC 8 μg mL-1) against S. aureus. These results pave the way for the synthesis of simple, cost-effective yet potent lipopeptidomimetic antimicrobials.",

author = "Girt, {Georgina C.} and Amit Mahindra and {Al Jabri}, {Zaaima J.H.} and {De Ste Croix}, Megan and Oggioni, {Marco R.} and Jamieson, {Andrew G.}",

note = "Publisher Copyright: {\textcopyright} 2018 The Royal Society of Chemistry.",

year = "2018",

doi = "10.1039/c7cc06093a",

language = "English",

volume = "54",

pages = "2767--2770",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "22",

}

TY - JOUR

T1 - Lipopeptidomimetics derived from teixobactin have potent antibacterial activity against

T2 - Staphylococcus aureus

AU - Girt, Georgina C.

AU - Mahindra, Amit

AU - Al Jabri, Zaaima J.H.

AU - De Ste Croix, Megan

AU - Oggioni, Marco R.

AU - Jamieson, Andrew G.

PY - 2018

Y1 - 2018

N2 - A series of lipopeptidomimetics derived from teixobactin have been prepared that probe the role of residues (1-6) as a membrane anchor and the function of enduracididine. The most active compounds, with a farnesyl tail and End10 to Lys10 or Orn10 substitution have potent activity (MIC 8 μg mL-1) against S. aureus. These results pave the way for the synthesis of simple, cost-effective yet potent lipopeptidomimetic antimicrobials.

AB - A series of lipopeptidomimetics derived from teixobactin have been prepared that probe the role of residues (1-6) as a membrane anchor and the function of enduracididine. The most active compounds, with a farnesyl tail and End10 to Lys10 or Orn10 substitution have potent activity (MIC 8 μg mL-1) against S. aureus. These results pave the way for the synthesis of simple, cost-effective yet potent lipopeptidomimetic antimicrobials.

UR - http://www.scopus.com/inward/record.url?scp=85043786951&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85043786951&partnerID=8YFLogxK

U2 - 10.1039/c7cc06093a

DO - 10.1039/c7cc06093a

M3 - Article

C2 - 29484340

AN - SCOPUS:85043786951

SN - 1359-7345

VL - 54

SP - 2767

EP - 2770

JO - Chemical Communications

JF - Chemical Communications

IS - 22

ER -

Lipopeptidomimetics derived from teixobactin have potent antibacterial activity against: Staphylococcus aureus

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this