Lipopeptidomimetics derived from teixobactin have potent antibacterial activity against: Staphylococcus aureus

Georgina C. Girt; Amit Mahindra; Zaaima J.H. Al Jabri; Megan De Ste Croix; Marco R. Oggioni; Andrew G. Jamieson

doi:10.1039/c7cc06093a

Lipopeptidomimetics derived from teixobactin have potent antibacterial activity against: Staphylococcus aureus

Georgina C. Girt, Amit Mahindra, Zaaima J.H. Al Jabri, Megan De Ste Croix, Marco R. Oggioni, Andrew G. Jamieson^*

^*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلة › Article › مراجعة النظراء

14 اقتباسات (Scopus)

ملخص

A series of lipopeptidomimetics derived from teixobactin have been prepared that probe the role of residues (1-6) as a membrane anchor and the function of enduracididine. The most active compounds, with a farnesyl tail and End10 to Lys10 or Orn10 substitution have potent activity (MIC 8 μg mL^-1) against S. aureus. These results pave the way for the synthesis of simple, cost-effective yet potent lipopeptidomimetic antimicrobials.

اللغة الأصلية	English
الصفحات (من إلى)	2767-2770
عدد الصفحات	4
دورية	Chemical Communications
مستوى الصوت	54
رقم الإصدار	22
المعرِّفات الرقمية للأشياء	https://doi.org/10.1039/c7cc06093a
حالة النشر	Published - 2018
منشور خارجيًا	نعم

ASJC Scopus subject areas

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الوصول إلى المستند

10.1039/c7cc06093a

الملفات والروابط الأخرى

قم بذكر هذا

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title = "Lipopeptidomimetics derived from teixobactin have potent antibacterial activity against: Staphylococcus aureus",

abstract = "A series of lipopeptidomimetics derived from teixobactin have been prepared that probe the role of residues (1-6) as a membrane anchor and the function of enduracididine. The most active compounds, with a farnesyl tail and End10 to Lys10 or Orn10 substitution have potent activity (MIC 8 μg mL-1) against S. aureus. These results pave the way for the synthesis of simple, cost-effective yet potent lipopeptidomimetic antimicrobials.",

author = "Girt, {Georgina C.} and Amit Mahindra and {Al Jabri}, {Zaaima J.H.} and {De Ste Croix}, Megan and Oggioni, {Marco R.} and Jamieson, {Andrew G.}",

note = "Funding Information: The authors would like to thank the Universities of Leicester and Glasgow, the ERDF (IRSA) and Pepceuticals Ltd for funding. We gratefully acknowledge Mick Lee (University of Leicester) for LCMS and Gerry Griffith (University of Leicester) for NMR. Publisher Copyright: {\textcopyright} 2018 The Royal Society of Chemistry.",

year = "2018",

doi = "10.1039/c7cc06093a",

language = "English",

volume = "54",

pages = "2767--2770",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "22",

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TY - JOUR

T1 - Lipopeptidomimetics derived from teixobactin have potent antibacterial activity against

T2 - Staphylococcus aureus

AU - Girt, Georgina C.

AU - Mahindra, Amit

AU - Al Jabri, Zaaima J.H.

AU - De Ste Croix, Megan

AU - Oggioni, Marco R.

AU - Jamieson, Andrew G.

N1 - Funding Information: The authors would like to thank the Universities of Leicester and Glasgow, the ERDF (IRSA) and Pepceuticals Ltd for funding. We gratefully acknowledge Mick Lee (University of Leicester) for LCMS and Gerry Griffith (University of Leicester) for NMR. Publisher Copyright: © 2018 The Royal Society of Chemistry.

PY - 2018

Y1 - 2018

N2 - A series of lipopeptidomimetics derived from teixobactin have been prepared that probe the role of residues (1-6) as a membrane anchor and the function of enduracididine. The most active compounds, with a farnesyl tail and End10 to Lys10 or Orn10 substitution have potent activity (MIC 8 μg mL-1) against S. aureus. These results pave the way for the synthesis of simple, cost-effective yet potent lipopeptidomimetic antimicrobials.

AB - A series of lipopeptidomimetics derived from teixobactin have been prepared that probe the role of residues (1-6) as a membrane anchor and the function of enduracididine. The most active compounds, with a farnesyl tail and End10 to Lys10 or Orn10 substitution have potent activity (MIC 8 μg mL-1) against S. aureus. These results pave the way for the synthesis of simple, cost-effective yet potent lipopeptidomimetic antimicrobials.

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DO - 10.1039/c7cc06093a

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SN - 1359-7345

VL - 54

SP - 2767

EP - 2770

JO - Chemical Communications

JF - Chemical Communications

IS - 22

ER -

Lipopeptidomimetics derived from teixobactin have potent antibacterial activity against: Staphylococcus aureus

ملخص

ASJC Scopus subject areas

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