Abstract
Lipomatous ependymoma is a recently described entity and only 3 cases of this variant have been reported in the literature. We report 5 cases of this rare variant of ependymoma. Patients' age ranged from 4 years to 45 years and, interestingly, all of them were males. Two tumors were supratentorial in location, 2 in the fourth ventricle and 1 was intramedullary. Microscopically all of them showed the classical histology of ependymoma along with lipomatous differentiation. The lipomatous component was composed of cells with a large clear vacuole pushing the nucleus to the periphery and giving a signet ring cell appearance. This component demonstrated positivity for GFAP and S-100 protein thereby confirming its glial lineage. Three of the 5 tumors were high grade (WHO-grade III), had a high MIB-1 labelling index (MIB-1 LI) and showed recurrence on follow-up. However, 2 were low grade (WHO grade II) and patients are free of disease till the last follow up.
Original language | English |
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Pages (from-to) | 136-140 |
Number of pages | 5 |
Journal | Pathology and Oncology Research |
Volume | 6 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2000 |
Externally published | Yes |
Keywords
- Adipocyte
- Ependymoma
- Intracranial tumor
- Lipomatous change
- Metaplasia
- Signet ring cell
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Oncology
- Cancer Research