Ependymoma with extensive lipidization mimicking adipose tissue: A report of five cases

Mehar Chand Sharma, Rina Arora, Ritu Lakhtakia, Ashok Kumar Mahapatra, Chitra Sarkar*

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةمقالمراجعة النظراء

36 اقتباسات (Scopus)

ملخص

Lipomatous ependymoma is a recently described entity and only 3 cases of this variant have been reported in the literature. We report 5 cases of this rare variant of ependymoma. Patients' age ranged from 4 years to 45 years and, interestingly, all of them were males. Two tumors were supratentorial in location, 2 in the fourth ventricle and 1 was intramedullary. Microscopically all of them showed the classical histology of ependymoma along with lipomatous differentiation. The lipomatous component was composed of cells with a large clear vacuole pushing the nucleus to the periphery and giving a signet ring cell appearance. This component demonstrated positivity for GFAP and S-100 protein thereby confirming its glial lineage. Three of the 5 tumors were high grade (WHO-grade III), had a high MIB-1 labelling index (MIB-1 LI) and showed recurrence on follow-up. However, 2 were low grade (WHO grade II) and patients are free of disease till the last follow up.

اللغة الأصليةEnglish
الصفحات (من إلى)136-140
عدد الصفحات5
دوريةPathology and Oncology Research
مستوى الصوت6
رقم الإصدار2
المعرِّفات الرقمية للأشياء
حالة النشرPublished - 2000
منشور خارجيًانعم

ASJC Scopus subject areas

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