ملخص
The Pim-1 gene encodes for a serine/threonine protein kinase proto-oncogene involved in cytokine signaling as well as in various pathways regulating cell cycle and apoptosis. Pim-1 kinase plays an important role in the development of various tumors mainly, prostate cancer, Burkitt's lymphoma, oral cancer and various other hematopoietic lymphomas. This review will focus on the importance and mechanisms of Pim-1 in prostate cancer and the potential clinical relevance of its various inhibitors.
| اللغة الأصلية | English |
|---|---|
| الصفحات (من إلى) | 239-247 |
| عدد الصفحات | 9 |
| دورية | Frontiers in Bioscience - Elite |
| مستوى الصوت | 7E |
| رقم الإصدار | 2 |
| المعرِّفات الرقمية للأشياء | |
| حالة النشر | Published - يناير 15 2015 |
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