TY - JOUR
T1 - Coexistence of autism spectrum disorders among three children with tuberous sclerosis complex
T2 - Case reports and review of literature
AU - Al-Futaisi, Amna
AU - Idris, Ahmed
AU - Al-Sayegh, Abeer
AU - Al-Mamari, Watfa S.
N1 - Publisher Copyright:
© 2016, Sultan Qaboos University. All rights reserved.
PY - 2016/11
Y1 - 2016/11
N2 - Tuberous sclerosis complex (TSC) is a multisystem neurocutaneous disorder inherited in an autosomal dominant manner and characterised by benign tumours in the brain and other vital organs such as the heart, eyes, kidneys, skin and lungs. Links between autism spectrum disorder (ASD) and TSC have been postulated for many decades, with TSC considered to be one of the main syndromic causes of ASD; however, precise confirmation of a relationship between these two disorders required validated diagnostic tools. Fortunately, accurate evaluation of this relationship is now possible with standardised criteria for ASD diagnosis. We report three children who presented to the Sultan Qaboos University Hospital, Muscat, Oman, between 2014 and 2015 with ASD and TSC. These cases demonstrate the spectrum of neuropsychiatric involvement in TSC and highlight the importance of screening children with TSC for ASD features in order to encourage the early enrolment of these children in educational and rehabilitation programmes.
AB - Tuberous sclerosis complex (TSC) is a multisystem neurocutaneous disorder inherited in an autosomal dominant manner and characterised by benign tumours in the brain and other vital organs such as the heart, eyes, kidneys, skin and lungs. Links between autism spectrum disorder (ASD) and TSC have been postulated for many decades, with TSC considered to be one of the main syndromic causes of ASD; however, precise confirmation of a relationship between these two disorders required validated diagnostic tools. Fortunately, accurate evaluation of this relationship is now possible with standardised criteria for ASD diagnosis. We report three children who presented to the Sultan Qaboos University Hospital, Muscat, Oman, between 2014 and 2015 with ASD and TSC. These cases demonstrate the spectrum of neuropsychiatric involvement in TSC and highlight the importance of screening children with TSC for ASD features in order to encourage the early enrolment of these children in educational and rehabilitation programmes.
KW - Autism spectrum disorder
KW - Case report
KW - Oman
KW - Tuberous sclerosis
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U2 - 10.18295/squmj.2016.16.04.022
DO - 10.18295/squmj.2016.16.04.022
M3 - Article
AN - SCOPUS:85000908279
SN - 2075-051X
VL - 16
SP - e520-e524
JO - Sultan Qaboos University Medical Journal
JF - Sultan Qaboos University Medical Journal
IS - 4
ER -