TY - JOUR
T1 - An Estimate of Protective Immunity against SARS-CoV2
T2 - Comparison of Different Vaccine Types
AU - Iqbal, Waseem
AU - Ullah, Ikram
AU - Irum, Uroosa
AU - Siddiqi, Saima
AU - Khan, Khalid Mahmood
N1 - Publisher Copyright:
© 2023, Giunti. All rights reserved.
PY - 2023/8/24
Y1 - 2023/8/24
N2 - Several types of vaccines have been approved to prevent SARS-CoV-2 infection. Few studies are conducted on the efficacy of COVID-19 vaccines. Vaccination is important to eliminate and fight SARS-CoV-2 infection and several vaccines have been approved. This study aimed to assess the incidence density of COVID-19 infection among the community, estimate the effectiveness of different types of vaccines (inactivated virus, viral vector or mRNA) and efficiency of incomplete and complete vaccination. In this observational cross-sectional study, a total of 4924 specimens were received from 1st January 2022 to 2nd February 2022 for the detection of SARS-CoV-2. The patient’s age, gender, and vaccination data were recorded and S, N, and ORF 1ab genes were amplified after RNA extraction through PCR. out of which 1034 (20.99 %) cases were positive. Among 1034 (20.99 %) positive cases, 418 and 616 patients were vaccinated and non-vaccinated respectively. The cases of SARS-CoV-2 in vaccinated patients were categorized into a sudden infection (≤ 10 days) and late infection (≥10 days) after the incomplete and complete dose of vaccination. Vaccination provides partial protection against SARS-CoV-2 infection. This might be due to the low efficacy and inability to detect recent variations in the protein structure of the virus.
AB - Several types of vaccines have been approved to prevent SARS-CoV-2 infection. Few studies are conducted on the efficacy of COVID-19 vaccines. Vaccination is important to eliminate and fight SARS-CoV-2 infection and several vaccines have been approved. This study aimed to assess the incidence density of COVID-19 infection among the community, estimate the effectiveness of different types of vaccines (inactivated virus, viral vector or mRNA) and efficiency of incomplete and complete vaccination. In this observational cross-sectional study, a total of 4924 specimens were received from 1st January 2022 to 2nd February 2022 for the detection of SARS-CoV-2. The patient’s age, gender, and vaccination data were recorded and S, N, and ORF 1ab genes were amplified after RNA extraction through PCR. out of which 1034 (20.99 %) cases were positive. Among 1034 (20.99 %) positive cases, 418 and 616 patients were vaccinated and non-vaccinated respectively. The cases of SARS-CoV-2 in vaccinated patients were categorized into a sudden infection (≤ 10 days) and late infection (≥10 days) after the incomplete and complete dose of vaccination. Vaccination provides partial protection against SARS-CoV-2 infection. This might be due to the low efficacy and inability to detect recent variations in the protein structure of the virus.
KW - COVID-19 Vaccine Types
KW - Ct Valu
KW - SARS-COV-2
KW - Vaccine Effectiveness
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U2 - 10.53560/PPASB(60-3)749
DO - 10.53560/PPASB(60-3)749
M3 - Article
AN - SCOPUS:85174961593
SN - 2518-4261
VL - 60
SP - 377
EP - 382
JO - Proceedings of the Pakistan Academy of Sciences: Part B
JF - Proceedings of the Pakistan Academy of Sciences: Part B
IS - 3
ER -