TY - JOUR
T1 - Vanillin Attenuated Behavioural Impairments, Neurochemical Deficts, Oxidative Stress and Apoptosis Against Rotenone Induced Rat Model of Parkinson’s Disease
AU - Dhanalakshmi, Chinnasamy
AU - Janakiraman, Udaiyappan
AU - Manivasagam, Thamilarasan
AU - Justin Thenmozhi, Arokiasamy
AU - Essa, Musthafa Mohamed
AU - Kalandar, Ameer
AU - Khan, Mohammed Abdul Sattar
AU - Guillemin, Gilles J.
N1 - Publisher Copyright:
© 2016, Springer Science+Business Media New York.
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Vanillin (4-hydroxy-3-methoxybenzaldehyde), a pleasant smelling organic aromatic compound, is widely used as a flavoring additive in food, beverage, cosmetic and drug industries. It is reported to cross the blood brain barrier and also displayed antioxidant and neuroprotective activities. We previously reported the neuroprotective effect of vanillin against rotenone induced in in vitro model of PD. The present experiment was aimed to analyze the neuroprotective effect of vanillin on the motor and non-motor deficits, neurochemical variables, oxidative, anti-oxidative indices and the expression of apoptotic markers against rotenone induced rat model of Parkinson’s disease (PD). Rotenone treatment exhibited motor and non-motor impairments, neurochemical deficits, oxidative stress and apoptosis, whereas oral administration of vanillin attenuated the above-said indices. However further studies are needed to explore the mitochondrial protective and anti-inflammatory properties of vanillin, as these processes play a vital role in the cause and progression of PD.
AB - Vanillin (4-hydroxy-3-methoxybenzaldehyde), a pleasant smelling organic aromatic compound, is widely used as a flavoring additive in food, beverage, cosmetic and drug industries. It is reported to cross the blood brain barrier and also displayed antioxidant and neuroprotective activities. We previously reported the neuroprotective effect of vanillin against rotenone induced in in vitro model of PD. The present experiment was aimed to analyze the neuroprotective effect of vanillin on the motor and non-motor deficits, neurochemical variables, oxidative, anti-oxidative indices and the expression of apoptotic markers against rotenone induced rat model of Parkinson’s disease (PD). Rotenone treatment exhibited motor and non-motor impairments, neurochemical deficits, oxidative stress and apoptosis, whereas oral administration of vanillin attenuated the above-said indices. However further studies are needed to explore the mitochondrial protective and anti-inflammatory properties of vanillin, as these processes play a vital role in the cause and progression of PD.
KW - Motor and non-motor symptoms
KW - Oxidative stress, apoptosis
KW - Parkinson’s disease
KW - Vanillin
UR - http://www.scopus.com/inward/record.url?scp=84962163532&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84962163532&partnerID=8YFLogxK
U2 - 10.1007/s11064-016-1901-5
DO - 10.1007/s11064-016-1901-5
M3 - Article
C2 - 27038927
AN - SCOPUS:84962163532
SN - 0364-3190
VL - 41
SP - 1899
EP - 1910
JO - Neurochemical Research
JF - Neurochemical Research
IS - 8
ER -