Vaccination of calves against Salmonella dublin with aromatic-dependent Salmonella typhimurium.

B. P. Smith*, M. Reina-Guerra, B. A. Stocker, S. K. Hoiseth, E. H. Johnson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Ten Holstein calves were divided into 2 groups. Five calves served as nonvaccinated controls, and 5 calves were vaccinated IM at 2 and 3 weeks of age with 10(9) aromatic-dependent (aro-) Salmonella typhimurium strain SL1479 containing O antigens 1, 4, 12. Serious adverse reactions to vaccination were not observed in the calves. Mean maximum rectal temperature increase in the vaccinated calves was 1.5 C. One calf had diarrhea and depressed appetite for 1 day after vaccination. At 5 weeks of age, all calves were challenge exposed orally with 1.5 X 10(11) virulent S dublin strain SL1367 (O antigens 9,12). After challenge-exposure inoculum was given, 1 of 5 vaccinated calves died and 4 of the 5 nonvaccinated calves died (P less than 0.05). Thus, some cross serotype protection against S dublin was induced by parenteral vaccination of calves with aro- S typhimurium strain SL1479, although protection was not complete.

Original languageEnglish
Pages (from-to)1858-1861
Number of pages4
JournalAmerican Journal of Veterinary Research
Issue number9
Publication statusPublished - Sept 1984

ASJC Scopus subject areas

  • veterinary(all)


Dive into the research topics of 'Vaccination of calves against Salmonella dublin with aromatic-dependent Salmonella typhimurium.'. Together they form a unique fingerprint.

Cite this