Transient opsoclonus-myoclonus syndrome secondary to neuroblastoma

Roshan Koul*, Amna Al-Futaisi, Ranjan Williams, Hashim Javad, Alexander Chacko

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


We report a 2 1/2-year-old girl who presented with acute history of fluctuating level of consciousness in the form of drowsiness, extreme irritability, and involuntary abnormal movements in the form of shaking of the whole body. She was treated with acyclovir empirically, contemplating herpes simplex virus encephalitis. Overtime she improved substantially. The opsoclonus, myoclonus, and ataxia disappeared without treatment. However, 6 weeks later she presented again with classic opsoclonus-myoclonus syndrome. The investigations revealed neuroblastoma. This case illustrates that transient opsoclonus-myoclonus may occur with neuroblastoma and should not be assumed to be due to viral cause. Thus, a thorough search for occult neuroblastoma should be initiated even if opsoclonus-myoclonus resolves spontaneously.

Original languageEnglish
Pages (from-to)253-255
Number of pages3
Issue number3
Publication statusPublished - Jul 2007

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health


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