Transient myeloproliferative disorder and Down syndrome: Is there a link?

Zenaida S. Reyes; Wafa Bashir; Anil Pathare

doi:10.12816/0003177

Transient myeloproliferative disorder and Down syndrome: Is there a link?

Zenaida S. Reyes, Wafa Bashir, Anil Pathare

Haematology

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

An extremely premature male neonate presented with an unusual multisystem dysfunction within the first 24 to 48 hours of life. The unfolding of clinical events and investigations revealed a transient myeloproliferative disorder (TMD). TMD was the main indication for karyotyping of this premature infant without clinical symptoms of Down syndrome. The awareness of TMD in a newborn warrants karyotype analysis to look for trisomy 21 and a close surveillance because of its potential progression to true leukaemia.

Original language	English
Pages (from-to)	498-502
Number of pages	5
Journal	Sultan Qaboos University Medical Journal
Volume	12
Issue number	4
DOIs	https://doi.org/10.12816/0003177
Publication status	Published - Nov 2012

Keywords

Acute myelogenous leukemia (AML)
Case report
Down syndrome
Extreme premature
GATA1
Oman
Transient myeloproliferative disorder

ASJC Scopus subject areas

Medicine(all)

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10.12816/0003177

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title = "Transient myeloproliferative disorder and Down syndrome: Is there a link?",

abstract = "An extremely premature male neonate presented with an unusual multisystem dysfunction within the first 24 to 48 hours of life. The unfolding of clinical events and investigations revealed a transient myeloproliferative disorder (TMD). TMD was the main indication for karyotyping of this premature infant without clinical symptoms of Down syndrome. The awareness of TMD in a newborn warrants karyotype analysis to look for trisomy 21 and a close surveillance because of its potential progression to true leukaemia.",

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KW - GATA1

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Transient myeloproliferative disorder and Down syndrome: Is there a link?

Abstract

Keywords

ASJC Scopus subject areas

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