Tin disulfide nanorod-graphene-β-cyclodextrin nanocomposites for sensing dopamine in rat brains and human blood serum

Sridharan Balu, Selvakumar Palanisamy*, Vijaylakshmi Velusamy, Thomas C.K. Yang, El Said I. El-Shafey

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


In the present work describes a facile synthesis of tin disulfide (SnS2) nanorods decorated graphene-β-cyclodextrin (SnS2/GR-β-CD) nanocomposite for robust and novel dopamine (DA) electrochemical biosensor applications. The DA biosensor was fabricated using the glassy carbon electrode (GCE) modified with SnS2/GR-β-CD nanocomposite. The sonochemical and hydrothermal methods have been used for the synthesis of SnS2/GR-β-CD. Different physicochemical methods were used to confirm the formation of the GR-β-CD, SnS2, and SnS2/GR-β-CD nanocomposite. The cyclicvoltammetric cathodic current response of DA was 5 folds higher than those observed at bare, β-CD, SnS2-β-CD, and GR-β-CD modified GCEs. Under optimised conditions, the biosensor's DPV response current is linear to DA from the concentration of 0.01–150.76 μM. The detection limit of the biosensor was 4 nM. The SnS2/GR-β-CD biosensor shows an excellent selectivity towards DA in the presence of common interfering species, including ascorbic acid and uric acid. Also, the as-prepared nanocomposite-modified electrode exhibited satisfactory long-term stability, sensitivity (2.49 μAμM−1 cm−2) along with reusability for detection of DA. The fabricated SnS2/GR-β-CD biosensor was successfully used for the detection of DA in the rat brain and human blood serum samples.

Original languageEnglish
Article number110367
Pages (from-to)110367
JournalMaterials Science and Engineering C
Publication statusPublished - Mar 2020


  • Biosensor
  • Dopamine
  • Graphene nanocomposite
  • Guest-host chemistry
  • SnS nanorods
  • Sonochemical method
  • Nanotubes/chemistry
  • Limit of Detection
  • Electrochemical Techniques
  • Oxidation-Reduction
  • Disulfides/chemistry
  • Humans
  • Dopamine/blood
  • Rats
  • beta-Cyclodextrins/chemistry
  • Graphite/chemistry
  • Tin/chemistry
  • Animals
  • X-Ray Diffraction
  • Biosensing Techniques
  • Nanocomposites/chemistry
  • Brain/metabolism

ASJC Scopus subject areas

  • General Materials Science
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering


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