Time-frequency analysis of heart rate variability in neonatal piglets exposed to hypoxia

Shiying Dong*, Mostefa Mesbah, Barbara E. Lingwood, John M. O'Toole, Boualem Boashash

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Citations (Scopus)


To determine whether the sympathetic nervous system plays any role in the inter-individual variation of cardiovascular response to hypoxia in newborns, neonatal heart rate variability (HRV) analysis was used to assess autonomic response during hypoxia in piglets. Due to the nonstationary nature of HRV signals and the inaccuracy in pre-defined neonatal HRV frequency bands using standard spectral methods, we applied time-frequency distribution analysis to assess neonatal HRV. Although sympathetic activity was initially enhanced to stimulate the cardiac compensation, it did not account for the variation of cardiovascular response since the power of low frequency component in HRV neither showed corresponding changes with the heart rate nor had any correlation with the brain injury. This may be attributed to immaturity of the neural pathway.

Original languageEnglish
Title of host publicationComputing in Cardiology 2011, CinC 2011
Number of pages4
Publication statusPublished - 2011
Externally publishedYes
EventComputing in Cardiology 2011, CinC 2011 - Hangzhou, China
Duration: Sept 18 2011Sept 21 2011

Publication series

NameComputing in Cardiology
ISSN (Print)2325-8861
ISSN (Electronic)2325-887X


OtherComputing in Cardiology 2011, CinC 2011

ASJC Scopus subject areas

  • General Computer Science
  • Cardiology and Cardiovascular Medicine


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