The role of fractional anisotropy (Fa) in alzheimer's disease and people without alzheimer's: A review

Patcharaporn Srisaikaew, Srijit Das, Pasuk Mahakkanukrauh*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Objective: This study aimed to use the diffusion tensor imaging technique to trace the white matter bundles of the fornix in humans both with and without Alzheimer's disease to identify differentiation and the connectivity in the fornix. The aim was to facilitate the early diagnosis of Alzheimer's disease which will be of direct benefit to patients. Materials and Methods: Databases, including PubMed, Scopus, Google Scholar and Elsevier and Springer Verlag were searched to identify relevant scientific papers and other literature pertinent to diffusion tensor imaging into Alzheimer's disease patients. Result: The abnormalities in the white matter microstructure of the fornix could lead to Alzheimer's disease, which causes problems mainly associated with memory. Early diagnosis of Alzheimer's disease specificity from fornix degeneration is crucial. Conclusion: Early diagnosis is helpful for both patients and the neurologist for planning therapy for long-term quality of life. When using diffusion tensor imaging (DTI), the parameter called fractional anisotropy (FA) is a biomarker for the disease.

Original languageEnglish
Pages (from-to)262-265
Number of pages4
JournalInternational Medical Journal
Issue number4
Publication statusPublished - 2019


  • Alzheimer's disease
  • Diffusion tensor imaging
  • Fornix
  • Magnetic resonance imaging's
  • Neurotransmitter

ASJC Scopus subject areas

  • Medicine(all)


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