The risk and associated factors of methamphetamine psychosis in methamphetamine-dependent patients in Malaysia

Ahmad Hatim Sulaiman*, Mas Ayu Said, Mohd Hussain Habil, Rusdi Rashid, Amer Siddiq, Ng Chong Guan, Marhani Midin, Nik Ruzyanei Nik Jaafar, Hatta Sidi, Srijit Das

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)


Objective The objective of this study was to determine the risk of lifetime and current methamphetamine-induced psychosis in patients with methamphetamine dependence. The association between psychiatric co-morbidity and methamphetamine-induced psychosis was also studied. Methods This was a cross-sectional study conducted concurrently at a teaching hospital and a drug rehabilitation center in Malaysia. Patients with the diagnosis of methamphetamine based on DSM-IV were interviewed using the Mini International Neuropsychiatric Interview (M.I.N.I.) for methamphetamine-induced psychosis and other Axis I psychiatric disorders. The information on sociodemographic background and drug use history was obtained from interview or medical records. Results Of 292 subjects, 47.9% of the subjects had a past history of psychotic symptoms and 13.0% of the patients were having current psychotic symptoms. Co-morbid major depressive disorder (OR = 7.18, 95 CI = 2.612-19.708), bipolar disorder (OR = 13.807, 95 CI = 5.194-36.706), antisocial personality disorder (OR = 12.619, 95 CI = 6.702-23.759) and heavy methamphetamine uses were significantly associated with lifetime methamphetamine-induced psychosis after adjusted for other factors. Major depressive disorder (OR = 2.870, CI = 1.154-7.142) and antisocial personality disorder (OR = 3.299, 95 CI = 1.375-7.914) were the only factors associated with current psychosis. Conclusion There was a high risk of psychosis in patients with methamphetamine dependence. It was associated with co-morbid affective disorder, antisocial personality, and heavy methamphetamine use. It is recommended that all cases of methamphetamine dependence should be screened for psychotic symptoms.

Original languageEnglish
Pages (from-to)S89-S94
JournalComprehensive Psychiatry
Issue numberSUPPL. 1
Publication statusPublished - Jan 2014
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health


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