The need for new anti-hepatitis C virus therapeutic strategies: Targeting the cellular micro-ribonucleic acids?

Elias A. Said

The need for new anti-hepatitis C virus therapeutic strategies: Targeting the cellular micro-ribonucleic acids?

Elias A. Said^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

1 Citation (Scopus)

Abstract

Infection with the hepatitis C virus (HCV) is a worldwide problem. Patients with chronic HCV infection who are non-responders to standard therapy represent a growing population within the HCV epidemic. Novel, more efficient and tolerable therapies are urgently needed. This review discusses the recent results showing that targeting miR-122, a micro-ribonucleic acid (MicroRNA) that enhances HCV replication, is a new anti-HCV therapy with a high barrier to resistance.

Original language	English
Pages (from-to)	312-317
Number of pages	6
Journal	Sultan Qaboos University Medical Journal
Volume	10
Issue number	3
Publication status	Published - Dec 2010
Externally published	Yes

Keywords

Hepatitis C virus
Infection
Interferon
Liver
MicroRNAs
Therapy

ASJC Scopus subject areas

Medicine(all)

Cite this

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title = "The need for new anti-hepatitis C virus therapeutic strategies: Targeting the cellular micro-ribonucleic acids?",

abstract = "Infection with the hepatitis C virus (HCV) is a worldwide problem. Patients with chronic HCV infection who are non-responders to standard therapy represent a growing population within the HCV epidemic. Novel, more efficient and tolerable therapies are urgently needed. This review discusses the recent results showing that targeting miR-122, a micro-ribonucleic acid (MicroRNA) that enhances HCV replication, is a new anti-HCV therapy with a high barrier to resistance.",

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AU - Said, Elias A.

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N2 - Infection with the hepatitis C virus (HCV) is a worldwide problem. Patients with chronic HCV infection who are non-responders to standard therapy represent a growing population within the HCV epidemic. Novel, more efficient and tolerable therapies are urgently needed. This review discusses the recent results showing that targeting miR-122, a micro-ribonucleic acid (MicroRNA) that enhances HCV replication, is a new anti-HCV therapy with a high barrier to resistance.

AB - Infection with the hepatitis C virus (HCV) is a worldwide problem. Patients with chronic HCV infection who are non-responders to standard therapy represent a growing population within the HCV epidemic. Novel, more efficient and tolerable therapies are urgently needed. This review discusses the recent results showing that targeting miR-122, a micro-ribonucleic acid (MicroRNA) that enhances HCV replication, is a new anti-HCV therapy with a high barrier to resistance.

KW - Hepatitis C virus

KW - Infection

KW - Interferon

KW - Liver

KW - MicroRNAs

KW - Therapy

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M3 - Review article

AN - SCOPUS:84870288172

SN - 2075-051X

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JO - Sultan Qaboos University Medical Journal

JF - Sultan Qaboos University Medical Journal

IS - 3

ER -

The need for new anti-hepatitis C virus therapeutic strategies: Targeting the cellular micro-ribonucleic acids?

Abstract

Keywords

ASJC Scopus subject areas

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