The mortality of COVID-19 in CML patients from 2020 until 2022: results from the EPICOVIDEHA survey

Shaimaa El-Ashwah; Jon Salmanton-García; Yavuz M. Bilgin; Federico Itri; Pavel Žák; Barbora Weinbergerová; Luisa Verga; Ali S. Omrani; Maria Gomes da Silva; Tomáš Szotkowski; Monia Marchetti; Caterina Buquicchio; Marcio Nucci; Martin Schönlein; Francesca Farina; Caroline Besson; Lucia Prezioso; Summiya Nizamuddin; Julio Dávila-Valls; Sonia Martín-Pérez; Valentina Bonuomo; Jaap Van Doesum; Maria Chiara Tisi; Francesco Passamonti; Gustavo Adolfo Méndez; Stef Meers; Johan Maertens; Alberto López-García; Andreas Glenthøj; Matteo Bonnani; Ikhwan Rinaldi; Irati Ormazabal-Vélez; Jorge Labrador; Austin Kulasekararaj; Ildefonso Espigado; Fatih Demirkan; Nick De Jonge; Graham P. Collins; Maria Calbacho; Ola Blennow; Murtadha Al-Khabori; Tatjana Adžić-Vukičević; Elena Arellano; Bojana Mišković; Miloš Mladenović; Anna Nordlander; Zdeněk Ráčil; Emanuele Ammatuna; Raul Cordoba; Ditte Stampe Hersby; Stefanie Gräfe; Ziad Emarah; Michaela Hanakova; Maria Vittoria Sacchi; Marriyam Ijaz; Laman Rahimli; Raquel Nunes Rodrigues; Giovanni Paolo Maria Zambrotta; Francesco Marchesi; Oliver A. Cornely; Livio Pagano

doi:10.1080/10428194.2023.2280886

The mortality of COVID-19 in CML patients from 2020 until 2022: results from the EPICOVIDEHA survey

Shaimaa El-Ashwah, Jon Salmanton-García^*, Yavuz M. Bilgin, Federico Itri, Pavel Žák, Barbora Weinbergerová, Luisa Verga, Ali S. Omrani, Maria Gomes da Silva, Tomáš Szotkowski, Monia Marchetti, Caterina Buquicchio, Marcio Nucci, Martin Schönlein, Francesca Farina, Caroline Besson, Lucia Prezioso, Summiya Nizamuddin, Julio Dávila-Valls, Sonia Martín-PérezValentina Bonuomo, Jaap Van Doesum, Maria Chiara Tisi, Francesco Passamonti, Gustavo Adolfo Méndez, Stef Meers, Johan Maertens, Alberto López-García, Andreas Glenthøj, Matteo Bonnani, Ikhwan Rinaldi, Irati Ormazabal-Vélez, Jorge Labrador, Austin Kulasekararaj, Ildefonso Espigado, Fatih Demirkan, Nick De Jonge, Graham P. Collins, Maria Calbacho, Ola Blennow, Murtadha Al-Khabori, Tatjana Adžić-Vukičević, Elena Arellano, Bojana Mišković, Miloš Mladenović, Anna Nordlander, Zdeněk Ráčil, Emanuele Ammatuna, Raul Cordoba, Ditte Stampe Hersby, Stefanie Gräfe, Ziad Emarah, Michaela Hanakova, Maria Vittoria Sacchi, Marriyam Ijaz, Laman Rahimli, Raquel Nunes Rodrigues, Giovanni Paolo Maria Zambrotta, Francesco Marchesi, Oliver A. Cornely, Livio Pagano

^*Corresponding author for this work

Haematology

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Since the beginning of the COVID-19 pandemic, there has been an overall improvement in patient mortality. However, haematological malignancy patients continue to experience significant impacts from COVID-19, including high rates of hospitalization, intensive care unit (ICU) admissions, and mortality. In comparison to other haematological malignancy patients, individuals with chronic myeloid leukemia (CML) generally have better prognosis. This study, conducted using a large haematological malignancy patient database (EPICOVIDEHA), demonstrated that the majority of CML patients experienced mild infections. The decline in severe and critical infections over the years can largely be attributed to the widespread administration of vaccinations and the positive response they elicited. Notably, the mortality rate among CML patients was low and exhibited a downward trend in subsequent years. Importantly, our analysis provided confirmation of the effectiveness of vaccinations in CML patients.

Original language	English
Pages (from-to)	1-10
Number of pages	10
Journal	Leukemia and Lymphoma
Volume	65
Issue number	2
DOIs	https://doi.org/10.1080/10428194.2023.2280886
Publication status	Published - Nov 15 2023

Keywords

COVID-19
Chronic myeloid leukemia
SARS-CoV-2
neoplasia
tirosine kinase inhibitor
vaccines

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/10428194.2023.2280886

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El-Ashwah, S., Salmanton-García, J., Bilgin, Y. M., Itri, F., Žák, P., Weinbergerová, B., Verga, L., Omrani, A. S., Silva, M. G. D., Szotkowski, T., Marchetti, M., Buquicchio, C., Nucci, M., Schönlein, M., Farina, F., Besson, C., Prezioso, L., Nizamuddin, S., Dávila-Valls, J., ... Pagano, L. (2023). The mortality of COVID-19 in CML patients from 2020 until 2022: results from the EPICOVIDEHA survey. Leukemia and Lymphoma, 65(2), 1-10. https://doi.org/10.1080/10428194.2023.2280886

El-Ashwah, S, Salmanton-García, J, Bilgin, YM, Itri, F, Žák, P, Weinbergerová, B, Verga, L, Omrani, AS, Silva, MGD, Szotkowski, T, Marchetti, M, Buquicchio, C, Nucci, M, Schönlein, M, Farina, F, Besson, C, Prezioso, L, Nizamuddin, S, Dávila-Valls, J, Martín-Pérez, S, Bonuomo, V, Van Doesum, J, Tisi, MC, Passamonti, F, Méndez, GA, Meers, S, Maertens, J, López-García, A, Glenthøj, A, Bonnani, M, Rinaldi, I, Ormazabal-Vélez, I, Labrador, J, Kulasekararaj, A, Espigado, I, Demirkan, F, De Jonge, N, Collins, GP, Calbacho, M, Blennow, O, Al-Khabori, M, Adžić-Vukičević, T, Arellano, E, Mišković, B, Mladenović, M, Nordlander, A, Ráčil, Z, Ammatuna, E, Cordoba, R, Hersby, DS, Gräfe, S, Emarah, Z, Hanakova, M, Sacchi, MV, Ijaz, M, Rahimli, L, Nunes Rodrigues, R, Zambrotta, GPM, Marchesi, F, Cornely, OA & Pagano, L 2023, 'The mortality of COVID-19 in CML patients from 2020 until 2022: results from the EPICOVIDEHA survey', Leukemia and Lymphoma, vol. 65, no. 2, pp. 1-10. https://doi.org/10.1080/10428194.2023.2280886

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abstract = "Since the beginning of the COVID-19 pandemic, there has been an overall improvement in patient mortality. However, haematological malignancy patients continue to experience significant impacts from COVID-19, including high rates of hospitalization, intensive care unit (ICU) admissions, and mortality. In comparison to other haematological malignancy patients, individuals with chronic myeloid leukemia (CML) generally have better prognosis. This study, conducted using a large haematological malignancy patient database (EPICOVIDEHA), demonstrated that the majority of CML patients experienced mild infections. The decline in severe and critical infections over the years can largely be attributed to the widespread administration of vaccinations and the positive response they elicited. Notably, the mortality rate among CML patients was low and exhibited a downward trend in subsequent years. Importantly, our analysis provided confirmation of the effectiveness of vaccinations in CML patients.",

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doi = "10.1080/10428194.2023.2280886",

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AU - El-Ashwah, Shaimaa

AU - Salmanton-García, Jon

AU - Bilgin, Yavuz M.

AU - Itri, Federico

AU - Žák, Pavel

AU - Weinbergerová, Barbora

AU - Verga, Luisa

AU - Omrani, Ali S.

AU - Silva, Maria Gomes da

AU - Szotkowski, Tomáš

AU - Marchetti, Monia

AU - Buquicchio, Caterina

AU - Nucci, Marcio

AU - Schönlein, Martin

AU - Farina, Francesca

AU - Besson, Caroline

AU - Prezioso, Lucia

AU - Nizamuddin, Summiya

AU - Dávila-Valls, Julio

AU - Martín-Pérez, Sonia

AU - Bonuomo, Valentina

AU - Van Doesum, Jaap

AU - Tisi, Maria Chiara

AU - Passamonti, Francesco

AU - Méndez, Gustavo Adolfo

AU - Meers, Stef

AU - Maertens, Johan

AU - López-García, Alberto

AU - Glenthøj, Andreas

AU - Bonnani, Matteo

AU - Rinaldi, Ikhwan

AU - Ormazabal-Vélez, Irati

AU - Labrador, Jorge

AU - Kulasekararaj, Austin

AU - Espigado, Ildefonso

AU - Demirkan, Fatih

AU - De Jonge, Nick

AU - Collins, Graham P.

AU - Calbacho, Maria

AU - Blennow, Ola

AU - Al-Khabori, Murtadha

AU - Adžić-Vukičević, Tatjana

AU - Arellano, Elena

AU - Mišković, Bojana

AU - Mladenović, Miloš

AU - Nordlander, Anna

AU - Ráčil, Zdeněk

AU - Ammatuna, Emanuele

AU - Cordoba, Raul

AU - Hersby, Ditte Stampe

AU - Gräfe, Stefanie

AU - Emarah, Ziad

AU - Hanakova, Michaela

AU - Sacchi, Maria Vittoria

AU - Ijaz, Marriyam

AU - Rahimli, Laman

AU - Nunes Rodrigues, Raquel

AU - Zambrotta, Giovanni Paolo Maria

AU - Marchesi, Francesco

AU - Cornely, Oliver A.

AU - Pagano, Livio

PY - 2023/11/15

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AB - Since the beginning of the COVID-19 pandemic, there has been an overall improvement in patient mortality. However, haematological malignancy patients continue to experience significant impacts from COVID-19, including high rates of hospitalization, intensive care unit (ICU) admissions, and mortality. In comparison to other haematological malignancy patients, individuals with chronic myeloid leukemia (CML) generally have better prognosis. This study, conducted using a large haematological malignancy patient database (EPICOVIDEHA), demonstrated that the majority of CML patients experienced mild infections. The decline in severe and critical infections over the years can largely be attributed to the widespread administration of vaccinations and the positive response they elicited. Notably, the mortality rate among CML patients was low and exhibited a downward trend in subsequent years. Importantly, our analysis provided confirmation of the effectiveness of vaccinations in CML patients.

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KW - Chronic myeloid leukemia

KW - SARS-CoV-2

KW - neoplasia

KW - tirosine kinase inhibitor

KW - vaccines

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The mortality of COVID-19 in CML patients from 2020 until 2022: results from the EPICOVIDEHA survey

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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