The effect of gentamicin on acetylsalicylic acid-induced platelet antiaggregatory action in mouse pial arterioles

F. M. El-Sabban; B. H. Ali; A. K. Bashir; M. O.M. Tanira

doi:10.1016/S0024-3205(98)00070-8

The effect of gentamicin on acetylsalicylic acid-induced platelet antiaggregatory action in mouse pial arterioles

F. M. El-Sabban, B. H. Ali^*, A. K. Bashir, M. O.M. Tanira

^*Corresponding author for this work

Pharmacology & Clinical Pharmacy

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Gentamicin (G) treatment (5, 20, 40 and 80 mg kg^-1 day^-1 given intramuscularly for 6 days) was shown to cause a dose-related platelet proaggregatory effect in mouse pial microcirculation. This was associated with a reduction in mouse renal function, indicated by high plasma creatinine and urea concentrations. When G was given at the same doses but as a single injection, it caused no change in renal function or platelet aggregation. Gentamicin (20 and 80 mg kg/day, given intramuscularly for 6 days) significantly (P < 0.05) impeded the platelet antiaggregatory effect of acetylsalicylic acid (100 mg kg^-1, intraperitoneally).

Original language	English
Pages (from-to)	1361-1369
Number of pages	9
Journal	Life Sciences
Volume	62
Issue number	15
DOIs	https://doi.org/10.1016/S0024-3205(98)00070-8
Publication status	Published - Mar 6 1998

Keywords

Acetylsalicylic acid
Gentamicin
Mice
Pial circulation
Platelet aggregation

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/S0024-3205(98)00070-8

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title = "The effect of gentamicin on acetylsalicylic acid-induced platelet antiaggregatory action in mouse pial arterioles",

abstract = "Gentamicin (G) treatment (5, 20, 40 and 80 mg kg-1 day-1 given intramuscularly for 6 days) was shown to cause a dose-related platelet proaggregatory effect in mouse pial microcirculation. This was associated with a reduction in mouse renal function, indicated by high plasma creatinine and urea concentrations. When G was given at the same doses but as a single injection, it caused no change in renal function or platelet aggregation. Gentamicin (20 and 80 mg kg/day, given intramuscularly for 6 days) significantly (P < 0.05) impeded the platelet antiaggregatory effect of acetylsalicylic acid (100 mg kg-1, intraperitoneally).",

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AU - El-Sabban, F. M.

AU - Ali, B. H.

AU - Bashir, A. K.

AU - Tanira, M. O.M.

PY - 1998/3/6

Y1 - 1998/3/6

N2 - Gentamicin (G) treatment (5, 20, 40 and 80 mg kg-1 day-1 given intramuscularly for 6 days) was shown to cause a dose-related platelet proaggregatory effect in mouse pial microcirculation. This was associated with a reduction in mouse renal function, indicated by high plasma creatinine and urea concentrations. When G was given at the same doses but as a single injection, it caused no change in renal function or platelet aggregation. Gentamicin (20 and 80 mg kg/day, given intramuscularly for 6 days) significantly (P < 0.05) impeded the platelet antiaggregatory effect of acetylsalicylic acid (100 mg kg-1, intraperitoneally).

AB - Gentamicin (G) treatment (5, 20, 40 and 80 mg kg-1 day-1 given intramuscularly for 6 days) was shown to cause a dose-related platelet proaggregatory effect in mouse pial microcirculation. This was associated with a reduction in mouse renal function, indicated by high plasma creatinine and urea concentrations. When G was given at the same doses but as a single injection, it caused no change in renal function or platelet aggregation. Gentamicin (20 and 80 mg kg/day, given intramuscularly for 6 days) significantly (P < 0.05) impeded the platelet antiaggregatory effect of acetylsalicylic acid (100 mg kg-1, intraperitoneally).

KW - Acetylsalicylic acid

KW - Gentamicin

KW - Mice

KW - Pial circulation

KW - Platelet aggregation

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The effect of gentamicin on acetylsalicylic acid-induced platelet antiaggregatory action in mouse pial arterioles

Abstract

Keywords

ASJC Scopus subject areas

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