Thalassaemia—A global view

Peter Hokland*, Shahina Daar, Wael Khair, Sujit Sheth, Ali T. Taher, Lorenza Torti, Chattree Hantaweepant, Deborah Rund*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

6 Citations (Scopus)


The thalassaemias are a group of genetic disorders of haemoglobin which are endemic in the tropics but are now found worldwide due to migration. Basic standard of care therapy includes regular transfusions to maintain a haemoglobin level of around 10 g/dL, together with iron chelation therapy to prevent iron overload. Novel therapies, bone marrow transplantation, and gene therapy are treatment options that are unavailable in many countries with stressed economies. This Wider Perspectives article presents the strategies for management of an adolescent refugee patient with beta thalassaemia, as it would be performed by expert haematologists in six countries: Italy, Lebanon, Oman, the Sudan, Thailand and the United States. The experienced clinicians in each country have adapted their practice according to the resources available, which vary greatly. Even in the current modern era, providing adequate transfusions and chelation is problematic in many countries. On the other hand, ensuring adherence to therapy, particularly during adolescence, is a similar challenge seen in all countries. The concluding section highlights the disparities in available therapies and puts the role of novel therapies into a societal context.

Original languageEnglish
Pages (from-to)199-214
Number of pages16
JournalBritish Journal of Haematology
Issue number2
Publication statusPublished - Feb 17 2023


  • diagnosis
  • global view
  • refugee
  • thalassaemia
  • therapy
  • Blood Transfusion
  • Humans
  • Thalassemia/epidemiology
  • Adolescent
  • Iron Overload/therapy
  • Chelation Therapy
  • beta-Thalassemia/epidemiology

ASJC Scopus subject areas

  • Hematology

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