Synthesis and pharmacological activity of 4-(4′-(chlorophenyl)-4- hydroxypiperidine) derivatives

Zafar Saeed Saify*, Nousheen Mushtaq, Khalid Mohammed Khan, Shahnaz Perveen, Syed Tasadaque Ali Shah, Raid Jamil Abdel-Jalil, Miriam Fecker, Wolfgang Voelter

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


A new series of 4-(4′-chlorophenyl)-4-hydroxypiperidine derivatives (2-5), substituted at nitrogen, were synthesized and tested as potential analgesic compounds as well as evaluated for their effect on hypotensive activity. Results showed that all the derivatives exhibit significant analgesic activity in male Wistar rats at a dose of 50 mg/kg of body weight after intramuscular injection, when tested by thermal stimuli (tail flick test). Pethidine was used as reference drug. Compounds 2, 3 and 5 produced reduction in blood pressure in normotensive rat.

Original languageEnglish
Pages (from-to)64-66
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Issue number1
Publication statusPublished - Jan 2005
Externally publishedYes


  • Activity
  • Derivative
  • Piperidine

ASJC Scopus subject areas

  • General Chemistry
  • Drug Discovery


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