Synthesis and antitumor activity of 2-aryl-7-fluoro-6-(4-methyl-1-piperazinyl)-4(3H)-quinazolinones

Raid J. Abdel-Jalil; Hani M. Aldoqum; Mikdad T. Ayoub; Wolfgang Voelter

doi:10.3987/COM-05-10387

Synthesis and antitumor activity of 2-aryl-7-fluoro-6-(4-methyl-1-piperazinyl)-4(3H)-quinazolinones

Raid J. Abdel-Jalil^*, Hani M. Aldoqum, Mikdad T. Ayoub, Wolfgang Voelter

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

54 Citations (Scopus)

Abstract

A series of new 2-aryl-7-fluoro-6-(4-methyl-1-piperazinyl)-4(3H)-quinazolinones were prepared by the oxidative cyclization of the corresponding 2-arylidineamino-4-fluoro-5-(4-methyl-1-piperazinyl)benzamides. The new quinazolinones were evaluated for their antitumor activity.

Original language	English
Pages (from-to)	2061-2070
Number of pages	10
Journal	Heterocycles
Volume	65
Issue number	9
DOIs	https://doi.org/10.3987/COM-05-10387
Publication status	Published - Sept 1 2005
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Pharmacology
Organic Chemistry

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AU - Ayoub, Mikdad T.

AU - Voelter, Wolfgang

PY - 2005/9/1

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AB - A series of new 2-aryl-7-fluoro-6-(4-methyl-1-piperazinyl)-4(3H)-quinazolinones were prepared by the oxidative cyclization of the corresponding 2-arylidineamino-4-fluoro-5-(4-methyl-1-piperazinyl)benzamides. The new quinazolinones were evaluated for their antitumor activity.

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Synthesis and antitumor activity of 2-aryl-7-fluoro-6-(4-methyl-1-piperazinyl)-4(3H)-quinazolinones

Abstract

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