Synthesis and antitumor activity of 2-aryl-7-fluoro-6-(4-methyl-1-piperazinyl)-4(3H)-quinazolinones

Raid J. Abdel-Jalil*, Hani M. Aldoqum, Mikdad T. Ayoub, Wolfgang Voelter

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

55 Citations (Scopus)


A series of new 2-aryl-7-fluoro-6-(4-methyl-1-piperazinyl)-4(3H)-quinazolinones were prepared by the oxidative cyclization of the corresponding 2-arylidineamino-4-fluoro-5-(4-methyl-1-piperazinyl)benzamides. The new quinazolinones were evaluated for their antitumor activity.

Original languageEnglish
Pages (from-to)2061-2070
Number of pages10
Issue number9
Publication statusPublished - Sept 1 2005
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry


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