Abstract
Crescentic glomerulonephritis has been associated with several solid tumour malignancies. Only a few cases of nephropathy have been reported in association with tubo-ovarian/peritoneal malignancies. We report a 55-year-old female patient who presented to a tertiary care centre, Muscat, Oman, in 2022. She developed combined immune complex-mediated glomerulonephritis and pauci-immune necrotising crescentic vasculitis simultaneously with the diagnosis of tubo-ovarian/peritoneal cancer. The baseline estimated glomerular filtration rate (eGFR) was 13 mL/min. The patient received two doses of rituximab and three doses of pulse corticosteroids, leading to significant improvement in renal function and the disappearance of her proteinuria. The eGFR improved to >60mL/min; her proteinuria gradually resolved after 10 weeks of treatment. She was then given a combination chemotherapy treatment for tubo-ovarian/peritoneal cancer leading to a normalisation of her CA-125 after three months of therapy.
Original language | English |
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Pages (from-to) | 119-122 |
Number of pages | 4 |
Journal | Sultan Qaboos University Medical Journal |
Volume | 24 |
Issue number | 1 |
DOIs | |
Publication status | Published - Feb 28 2024 |
Externally published | Yes |
Keywords
- Case Report
- Chemotherapy
- Glomerulonephritis
- Oman
- Peritoneal Neoplasm
- Vasculitis
- Carcinoma
- CA-125 Antigen
- Humans
- Middle Aged
- Patients
- Female
- Glomerulonephritis/drug therapy
- Proteinuria
ASJC Scopus subject areas
- General Medicine