Spurious hyperbilirubinemia caused by naproxen

Nafila Al Riyami, Amanda C. Zimmerman, Frances M. Rosenberg, Daniel T. Holmes*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Objective: To confirm that the naproxen metabolite O-desmethylnaproxen interferes with the Jendrassik and Grof method for total bilirubin and was a possible cause of spurious hyperbilirubinemia in a case of naproxen overdose. Design and methods: Plasma was spiked with naproxen or O-desmethylnaproxen before total and direct bilirubin analysis. Results: O-desmethylnaproxen concentration showed a linear relationship with measured total bilirubin. Conclusion: O-demethylnaproxen interferes with the total bilirubin method. Interference of glucuronide metabolites of naproxen and O-demethylnaproxen is not excluded.

Original languageEnglish
Pages (from-to)129-131
Number of pages3
JournalClinical Biochemistry
Issue number1-2
Publication statusPublished - Jan 2009
Externally publishedYes


  • Bilirubin
  • Diazonium compounds
  • Naproxen
  • Spectrophotometry

ASJC Scopus subject areas

  • Clinical Biochemistry


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