Sleep and Gonadotrophin Hormones

Sushmitha Shivalingaiah, Sunanda Tuladhar, Arehally Mahalakshmi, Prathibha Muthukumar, Sudheer Yannam, Luay Rashan, Musthafa Essa, Surapaneni Mohan, Vishnu Veeraraghavan, Srinivasa Bolla, Saravana Chidambaram, M. Qoronfleh*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)


Sleep plays a key role in neuroendocrine functioning and glucose metabolism. Currently existing data reveal that restriction of sleep duration results in adverse health effects. Sleep plays an imperative role in endocrine systems. Sleep causes the episodic secretion of gonadotrophin through modulation of neurotransmitters activity. Research on the significance of sex and gonadotrophic hormone in causing sleep disparities and its effects on cognition among men and women is gaining increased awareness. Epidemiologic, preclinical, and clinical studies have reported that sleep deprivation causes alteration of metabolic endocrine functions, including reduced glucose tolerance, insulin sensitivity, and leptin levels with increased cortisol and ghrelin levels. Men with lesser levels of testosterone and women with elevated levels of progesterone are more susceptible to the effects of sleep restriction on cognition and emotion processing tasks. The present integrative review highlights the effects of sleep deprivation on sex and gonadotrophin hormones and its link to cognitive function.

Original languageEnglish
Pages (from-to)17-26
Number of pages10
JournalInternational Journal of Nutrition, Pharmacology, Neurological Diseases
Issue number1
Publication statusPublished - Jan 1 2021


  • Cognition
  • gonadotrophin hormones
  • sleep
  • sleep disorders

ASJC Scopus subject areas

  • Nutrition and Dietetics
  • Clinical Neurology
  • Pharmacology (medical)


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