Single dose darbepoetin alfa is useful in reducing red cell transfusions in leukemic children receiving chemotherapy

Mathew Zachariah; Mohamed Elshinawy; Abdulhakim Alrawas; Wafa Bashir; Ismail Elbeshlawi; Surekha Tony; Yasser Wali

doi:10.3109/08880018.2013.824527

Single dose darbepoetin alfa is useful in reducing red cell transfusions in leukemic children receiving chemotherapy

Mathew Zachariah, Mohamed Elshinawy^*, Abdulhakim Alrawas, Wafa Bashir, Ismail Elbeshlawi, Surekha Tony, Yasser Wali

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The role of erythropoiesis-stimulating agents (ESAs) in the management of chemotherapy-induced anemia (CIA) is becoming increasingly recognized in the field of medical oncology, with paucity of data in pediatrics. We evaluated the efficacy and tolerability of a single-dose darbepoetin alfa, a long-acting ESA, given to 35 pediatric acute lymphoblastic leukemia (ALL) children during induction chemotherapy. Compared to a retrospective control group, the studied patients have required significantly less units of packed red blood cells (0.88 units/patient in the studied group versus 2.04 units in controls), with no major side effects. We recommend further prospective double-blinded studies with more tailored dosing regimens in pediatric ALL cases and solid tumors.

Original language	English
Pages (from-to)	442-447
Number of pages	6
Journal	Pediatric Hematology and Oncology
Volume	31
Issue number	5
DOIs	https://doi.org/10.3109/08880018.2013.824527
Publication status	Published - Aug 2014

Keywords

Anemia
Chemotherapy
Darbepoetin alfa
Leukemia

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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title = "Single dose darbepoetin alfa is useful in reducing red cell transfusions in leukemic children receiving chemotherapy",

abstract = "The role of erythropoiesis-stimulating agents (ESAs) in the management of chemotherapy-induced anemia (CIA) is becoming increasingly recognized in the field of medical oncology, with paucity of data in pediatrics. We evaluated the efficacy and tolerability of a single-dose darbepoetin alfa, a long-acting ESA, given to 35 pediatric acute lymphoblastic leukemia (ALL) children during induction chemotherapy. Compared to a retrospective control group, the studied patients have required significantly less units of packed red blood cells (0.88 units/patient in the studied group versus 2.04 units in controls), with no major side effects. We recommend further prospective double-blinded studies with more tailored dosing regimens in pediatric ALL cases and solid tumors.",

keywords = "Anemia, Chemotherapy, Darbepoetin alfa, Leukemia",

author = "Mathew Zachariah and Mohamed Elshinawy and Abdulhakim Alrawas and Wafa Bashir and Ismail Elbeshlawi and Surekha Tony and Yasser Wali",

note = "Funding Information: The study was approved by the Medical Research and Ethics Committee of the College of Medicine, Sultan Qaboos University. Informed consent was obtained from all parents of the patients enrolled in the study including consent to use the electronic data of the historical control group.",

year = "2014",

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doi = "10.3109/08880018.2013.824527",

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AU - Zachariah, Mathew

AU - Elshinawy, Mohamed

AU - Alrawas, Abdulhakim

AU - Bashir, Wafa

AU - Elbeshlawi, Ismail

AU - Tony, Surekha

AU - Wali, Yasser

N1 - Funding Information: The study was approved by the Medical Research and Ethics Committee of the College of Medicine, Sultan Qaboos University. Informed consent was obtained from all parents of the patients enrolled in the study including consent to use the electronic data of the historical control group.

PY - 2014/8

Y1 - 2014/8

N2 - The role of erythropoiesis-stimulating agents (ESAs) in the management of chemotherapy-induced anemia (CIA) is becoming increasingly recognized in the field of medical oncology, with paucity of data in pediatrics. We evaluated the efficacy and tolerability of a single-dose darbepoetin alfa, a long-acting ESA, given to 35 pediatric acute lymphoblastic leukemia (ALL) children during induction chemotherapy. Compared to a retrospective control group, the studied patients have required significantly less units of packed red blood cells (0.88 units/patient in the studied group versus 2.04 units in controls), with no major side effects. We recommend further prospective double-blinded studies with more tailored dosing regimens in pediatric ALL cases and solid tumors.

AB - The role of erythropoiesis-stimulating agents (ESAs) in the management of chemotherapy-induced anemia (CIA) is becoming increasingly recognized in the field of medical oncology, with paucity of data in pediatrics. We evaluated the efficacy and tolerability of a single-dose darbepoetin alfa, a long-acting ESA, given to 35 pediatric acute lymphoblastic leukemia (ALL) children during induction chemotherapy. Compared to a retrospective control group, the studied patients have required significantly less units of packed red blood cells (0.88 units/patient in the studied group versus 2.04 units in controls), with no major side effects. We recommend further prospective double-blinded studies with more tailored dosing regimens in pediatric ALL cases and solid tumors.

KW - Anemia

KW - Chemotherapy

KW - Darbepoetin alfa

KW - Leukemia

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JF - Pediatric Hematology and Oncology

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ER -

Single dose darbepoetin alfa is useful in reducing red cell transfusions in leukemic children receiving chemotherapy

Abstract

Keywords

ASJC Scopus subject areas

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