Sarcoroseolides A-D, four undescribed cembranoids from the Red Sea soft coral Sarcophyton roseum

Mohammed M.A. Ahmed; Mohamed A. Albadry; Ehab A. Ragab; Elsayed M. El-Ghaly; Said K. Ismail; Zulfiqar Ali; Shabana I. Khan; Amar G. Chittiboyina; Ikhlas A. Khan

doi:10.1080/14786419.2020.1821015

Sarcoroseolides A-D, four undescribed cembranoids from the Red Sea soft coral Sarcophyton roseum

Mohammed M.A. Ahmed, Mohamed A. Albadry, Ehab A. Ragab^*, Elsayed M. El-Ghaly, Said K. Ismail, Zulfiqar Ali, Shabana I. Khan, Amar G. Chittiboyina, Ikhlas A. Khan

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Four undescribed cembranoids, sarcoroseolides A-D (1-4) along with nine reported related cembranoids (5-13) were isolated from the soft coral Sarcophyton roseum. The chemical structures of sarcoroseolides A-D were elucidated by extensive 1 D and 2 D NMR as well as HR-ESIMS spectroscopic data. Moreover, the geometric and absolute configurations were assigned by the modified Mosher’s method and/or NOESY experiments. The extract and the isolated metabolites were evaluated for their potential anti-inflammatory and cytotoxic activities.

Original language	English
Pages (from-to)	1842-1850
Number of pages	9
Journal	Natural Product Research
Volume	36
Issue number	7
DOIs	https://doi.org/10.1080/14786419.2020.1821015
Publication status	Published - Sept 18 2020
Externally published	Yes

Keywords

Sarcophyton roseum
Soft coral
cembranoids
sarcoroseolides A-D
Diterpenes/chemistry
Animals
Indian Ocean
Magnetic Resonance Spectroscopy
Molecular Structure
Anthozoa/chemistry

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Plant Science
Organic Chemistry

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10.1080/14786419.2020.1821015

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title = "Sarcoroseolides A-D, four undescribed cembranoids from the Red Sea soft coral Sarcophyton roseum",

abstract = "Four undescribed cembranoids, sarcoroseolides A-D (1-4) along with nine reported related cembranoids (5-13) were isolated from the soft coral Sarcophyton roseum. The chemical structures of sarcoroseolides A-D were elucidated by extensive 1 D and 2 D NMR as well as HR-ESIMS spectroscopic data. Moreover, the geometric and absolute configurations were assigned by the modified Mosher{\textquoteright}s method and/or NOESY experiments. The extract and the isolated metabolites were evaluated for their potential anti-inflammatory and cytotoxic activities.",

keywords = "Sarcophyton roseum, Soft coral, cembranoids, sarcoroseolides A-D, Diterpenes/chemistry, Animals, Indian Ocean, Magnetic Resonance Spectroscopy, Molecular Structure, Anthozoa/chemistry",

author = "Ahmed, {Mohammed M.A.} and Albadry, {Mohamed A.} and Ragab, {Ehab A.} and El-Ghaly, {Elsayed M.} and Ismail, {Said K.} and Zulfiqar Ali and Khan, {Shabana I.} and Chittiboyina, {Amar G.} and Khan, {Ikhlas A.}",

note = "Publisher Copyright: {\textcopyright} 2020 Informa UK Limited, trading as Taylor & Francis Group.",

year = "2020",

month = sep,

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doi = "10.1080/14786419.2020.1821015",

language = "English",

volume = "36",

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T1 - Sarcoroseolides A-D, four undescribed cembranoids from the Red Sea soft coral Sarcophyton roseum

AU - Ahmed, Mohammed M.A.

AU - Albadry, Mohamed A.

AU - Ragab, Ehab A.

AU - El-Ghaly, Elsayed M.

AU - Ismail, Said K.

AU - Ali, Zulfiqar

AU - Khan, Shabana I.

AU - Chittiboyina, Amar G.

AU - Khan, Ikhlas A.

PY - 2020/9/18

Y1 - 2020/9/18

N2 - Four undescribed cembranoids, sarcoroseolides A-D (1-4) along with nine reported related cembranoids (5-13) were isolated from the soft coral Sarcophyton roseum. The chemical structures of sarcoroseolides A-D were elucidated by extensive 1 D and 2 D NMR as well as HR-ESIMS spectroscopic data. Moreover, the geometric and absolute configurations were assigned by the modified Mosher’s method and/or NOESY experiments. The extract and the isolated metabolites were evaluated for their potential anti-inflammatory and cytotoxic activities.

AB - Four undescribed cembranoids, sarcoroseolides A-D (1-4) along with nine reported related cembranoids (5-13) were isolated from the soft coral Sarcophyton roseum. The chemical structures of sarcoroseolides A-D were elucidated by extensive 1 D and 2 D NMR as well as HR-ESIMS spectroscopic data. Moreover, the geometric and absolute configurations were assigned by the modified Mosher’s method and/or NOESY experiments. The extract and the isolated metabolites were evaluated for their potential anti-inflammatory and cytotoxic activities.

KW - Sarcophyton roseum

KW - Soft coral

KW - cembranoids

KW - sarcoroseolides A-D

KW - Diterpenes/chemistry

KW - Animals

KW - Indian Ocean

KW - Magnetic Resonance Spectroscopy

KW - Molecular Structure

KW - Anthozoa/chemistry

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SN - 1478-6419

VL - 36

SP - 1842

EP - 1850

JO - Natural Product Research

JF - Natural Product Research

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ER -

Sarcoroseolides A-D, four undescribed cembranoids from the Red Sea soft coral Sarcophyton roseum

Abstract

Keywords

ASJC Scopus subject areas

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