TY - JOUR
T1 - Ruthenium nanoparticles embedded poly(4-aminodiphenylamine) nanocomposites based determination of guaifenesin in real samples
AU - Al-Hinaai, Mohammed M.
AU - Kannan, Palanisamy
AU - Rather, Jahangir Ahmad
AU - Sheikh, Rayees Ahmad
AU - Samdani, Mohammad Shahzad
N1 - Publisher Copyright:
© 2023 The Author(s)
PY - 2024/1/1
Y1 - 2024/1/1
N2 - An efficient sensing surface is fabricated through incorporating ruthenium on electropolymerized poly-(4-aminodiphenylamine)(Padpa) film by potentiodynamic cycling of 4-aminodiphenylamine (4-adpa) in an acidic medium. The mechanism of electropolymerization comprises the conversion of protonated monomer to di-imine species and generates positively charged radical-intermediate via dimerization step. The surface morphology of deposited film on electrode surface is studied using SEM and XPS techniques. The electrocatalytic appraisal of constructed (Ru/Padpa/GCE) sensing interface is examined towards the electro-oxidation of guaifenesin (GUA) by differential pulse voltammetry (DPV), electrochemical impedance spectroscopy (EIS), and chronoamperometric (CA) methods. The Ru/Padpa/GCE sensing interface displayed a linear response of GUA from 1.5 to 45 µg/mL with the limit of detection (LOD) of 48.8 ng/mL (S/N = 3). The obtained higher activity of Ru/Padpa/GCE is mainly attributed to its larger active surface area, faster electron transfer kinetics, and higher catalytic sites from the interface. The Ru/Padpa/GCE sensing interface is further applied for the determination of GUA in pharmaceutical (cough syrup, and human urine) samples with a recovery of 97.1–101.0 %. The diffusion coefficient of GUA (1.51 × 10-6 cm2/s) is also obtained via theoretical electrochemical method, which ensures that Ru/Padpa/GCE sensing interface can be considered as a potential candidate for clinical diagnostic analysis.
AB - An efficient sensing surface is fabricated through incorporating ruthenium on electropolymerized poly-(4-aminodiphenylamine)(Padpa) film by potentiodynamic cycling of 4-aminodiphenylamine (4-adpa) in an acidic medium. The mechanism of electropolymerization comprises the conversion of protonated monomer to di-imine species and generates positively charged radical-intermediate via dimerization step. The surface morphology of deposited film on electrode surface is studied using SEM and XPS techniques. The electrocatalytic appraisal of constructed (Ru/Padpa/GCE) sensing interface is examined towards the electro-oxidation of guaifenesin (GUA) by differential pulse voltammetry (DPV), electrochemical impedance spectroscopy (EIS), and chronoamperometric (CA) methods. The Ru/Padpa/GCE sensing interface displayed a linear response of GUA from 1.5 to 45 µg/mL with the limit of detection (LOD) of 48.8 ng/mL (S/N = 3). The obtained higher activity of Ru/Padpa/GCE is mainly attributed to its larger active surface area, faster electron transfer kinetics, and higher catalytic sites from the interface. The Ru/Padpa/GCE sensing interface is further applied for the determination of GUA in pharmaceutical (cough syrup, and human urine) samples with a recovery of 97.1–101.0 %. The diffusion coefficient of GUA (1.51 × 10-6 cm2/s) is also obtained via theoretical electrochemical method, which ensures that Ru/Padpa/GCE sensing interface can be considered as a potential candidate for clinical diagnostic analysis.
KW - Conducting materials
KW - Cyclic voltammetry
KW - Electrochemistry
KW - Guaifenesin
KW - Nanoparticles
KW - Poly-(4-aminodiphenylamine)
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U2 - 10.1016/j.jscs.2023.101776
DO - 10.1016/j.jscs.2023.101776
M3 - Article
AN - SCOPUS:85179603103
SN - 1319-6103
VL - 28
JO - Journal of Saudi Chemical Society
JF - Journal of Saudi Chemical Society
IS - 1
M1 - 101776
ER -