Revised workflow practices in the management of acute invasive fungal sinusitis during the COVID-19 pandemic

R. Kurien*, L. Varghese, L. M. Cherian, R. Sundaresan, M. John, M. D. Mammen, R. R. Inja, A. Manesh, H. Paul, P. R. Gurijala, J. S. Michael, M. Thomas, K. P.P. Abhilash, A. M. Varghese, V. Rupa

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Objective: To document changes in evaluation protocols for acute invasive fungal sinusitis (AIFS) during the COVID-19 pandemic and to analyse concordance between clinical and histopathological diagnosis based on new practice guidelines. Methods: Protocols for patient evaluation with suspected AIFS both prior and during the COVID-19 period are described. Retrospective analysis of patients with suspected AIFS from May 1st to June 30th 2021 and the concordance between clinical and final diagnosis was done. Results: Among 171 patients with high clinical suspicion, 160 (93.6%) correlated with the final histopathological diagnosis of invasive fungal sinusitis, providing a 100% sensitivity, positive predictive value of 93.6% and a negative predictive value of 100%. Conclusion: Our study highlights a valuable screening tool with good accuracy involving emphasis on red flag signs in high-risk populations. This could be valuable in situations demanding avoidance of aerosol generating procedures and in resource limited settings facilitating early referral to higher centres.
Original languageEnglish
Pages (from-to)1314-1319
Number of pages6
JournalJournal of Laryngology and Otology
Issue number12
Publication statusPublished - Aug 16 2022
Externally publishedYes


  • COVID-19
  • Mucormycosis
  • Paranasal Sinuses
  • Sinusitis
  • Invasive Fungal Infections/diagnosis
  • Acute Disease
  • Pandemics
  • Humans
  • Workflow
  • Retrospective Studies
  • Sinusitis/diagnosis

ASJC Scopus subject areas

  • Otorhinolaryngology

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