Recent advances in microwave-assisted copper-catalyzed cross-coupling reactions

Younis Baqi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)


Cross-coupling reactions furnishing carbon–carbon (C–C) and carbon–heteroatom (C–X) bond is one of the most challenging tasks in organic syntheses. The early developed reaction protocols by Ullmann, Ullman–Goldberg, Cadiot–Chodkiewicz, Castro–Stephens, and Corey–House, utilizing elemental copper or its salts as catalyst have, for decades, attracted and inspired scientists. However, these reactions were suffering from the range of functional groups tolerated as well as severely restricted by the harsh reaction conditions often required high temperatures (150–200 C) for extended reaction time. Enormous efforts have been paid to develop and achieve more sustainable reaction conditions by applying the microwave irradiation. The use of controlled microwave heating dramatically reduces the time required and therefore resulting in increase in the yield as well as the efficiency of the reaction. This review is mainly focuses on the recent advances and applications of copper catalyzed cross-coupling generation of carbon–carbon and carbon–heteroatom bond under microwave technology.

Original languageEnglish
Article number46
Pages (from-to)1-35
Number of pages35
Issue number1
Publication statusPublished - Dec 31 2020


  • Cross-coupling reaction
  • Cu catalyst
  • Methodology
  • Microwave irradiation
  • Synthesis

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry


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