TY - JOUR
T1 - Recent advancements in glucose dysregulation and pharmacological management of osteoporosis in transfusion-dependent thalassemia (TDT)
T2 - an update of ICET-A (International Network of Clinicians for Endocrinopathies in Thalassemia and Adolescence Medicine)
AU - Tzoulis, Ploutarchos
AU - Yavropoulou, Maria P.
AU - Banchev, Atanas
AU - Modeva, Iskra
AU - Daar, Shahina
AU - De Sanctis, Vincenzo
N1 - Publisher Copyright:
© Mattioli 1885.
PY - 2023/6/14
Y1 - 2023/6/14
N2 - Purpose of review: The aim of this short review is to provide an update on glucose homeostasis, insulin secretion and pharmacological management of osteoporosis in transfusion-dependent thalassemia (TDT). Recent findings: A retrospective study, documenting the changes in glucose-insulin homeostasis from early childhood to young adulthood, has advanced our understanding of the evolution of glucose regulation in patients with TDT. Magnetic Resonance Imaging (T2* MRI) is considered to be a reliable tool to measure pancreatic iron overload. Continuous glucose monitoring systems (CGMS) can be used in early diagnosis of glucose dysregulation and in disease management in patients with already diagnosed diabetes. Oral glucose-lowering agents (GLAs) are effective and safe for the treatment of diabetes mellitus (DM) in patients with TDT, achieving adequate glycemic control for a substantial period of time. Current modalities for the management of osteoporosis in adults with TDT include inhibitors of bone remodeling such as bisphosphonates and denosumab as well as stimulators of bone formation (e.g., teriparatide), Considering the unique charac-teristics of osteoporosis associated with TDT, early diagnosis, treatment initiation and treatment duration are critical issues in the management this special population. Conclusions: Advances in the care of TDT patients have led to improved survival and quality of life. Nevertheless, many chronic endocrine complications still re-main. Their routine screening and a high index of suspicion are imperative in order to provide timely diagnosis and treatment. (www.actabiomedica.it).
AB - Purpose of review: The aim of this short review is to provide an update on glucose homeostasis, insulin secretion and pharmacological management of osteoporosis in transfusion-dependent thalassemia (TDT). Recent findings: A retrospective study, documenting the changes in glucose-insulin homeostasis from early childhood to young adulthood, has advanced our understanding of the evolution of glucose regulation in patients with TDT. Magnetic Resonance Imaging (T2* MRI) is considered to be a reliable tool to measure pancreatic iron overload. Continuous glucose monitoring systems (CGMS) can be used in early diagnosis of glucose dysregulation and in disease management in patients with already diagnosed diabetes. Oral glucose-lowering agents (GLAs) are effective and safe for the treatment of diabetes mellitus (DM) in patients with TDT, achieving adequate glycemic control for a substantial period of time. Current modalities for the management of osteoporosis in adults with TDT include inhibitors of bone remodeling such as bisphosphonates and denosumab as well as stimulators of bone formation (e.g., teriparatide), Considering the unique charac-teristics of osteoporosis associated with TDT, early diagnosis, treatment initiation and treatment duration are critical issues in the management this special population. Conclusions: Advances in the care of TDT patients have led to improved survival and quality of life. Nevertheless, many chronic endocrine complications still re-main. Their routine screening and a high index of suspicion are imperative in order to provide timely diagnosis and treatment. (www.actabiomedica.it).
KW - growth and endocrine disorders
KW - osteoporosis
KW - risk factors
KW - short stature
KW - Transfusion-dependent thalassemia
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U2 - 10.23750/abm.v94i3.14805
DO - 10.23750/abm.v94i3.14805
M3 - Review article
C2 - 37326257
AN - SCOPUS:85162931958
SN - 0392-4203
VL - 94
JO - Acta Biomedica
JF - Acta Biomedica
IS - 3
M1 - e2023178
ER -