Properties, classification and applications of lantibiotics from Gram-positive bacteria

Abigail Fernandes, Pranay Yadav, Omkar Nalawade, Sanket Joshi, Renitta Jobby*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter


During the last few decades a plethora of research has described the gene-encoded antimicrobial peptides from various organisms. Gram-positive bacteria are well known to synthesize ribosomal antibacterial peptides known as lantibiotics. A large number of these peptides have gained increasing attention from researchers due to their ability to hinder microbes residing in the same niche. The biosynthesis of lantibiotics comprises posttranslational modifications. Lantibiotics present an unprecedented structural feature of intramolecular rings that are added by the thioether amino acids lanthionine and 3-methyl lanthionine. This class of bacteriocin has evolved into two different lineages, type A and B depending upon the structural and functional properties. This chapter summarizes the current knowledge of the structures and properties of the relatively diverse lantibiotics from Gram-positive organisms. An emphasis is made on the properties of recently described peptides. Furthermore, the classes and mode of action of these peptides are described. An outlook of potential applications beyond food preservatives has also been presented that will facilitate the widespread implementation of these novel peptides.

Original languageEnglish
Title of host publicationLantibiotics as Alternative Therapeutics
Number of pages15
ISBN (Electronic)9780323991414
ISBN (Print)9780323991421
Publication statusPublished - Jan 1 2023


  • anticancer
  • antimicrobial peptides
  • Bacteriocin
  • nisin
  • posttranslational modifications

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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