Production of phenylacetic acid derivatives and 4-epiradicinol in culture by Curvularia lunata

Gouri B. Varma, Majekodunmi O. Fatope*, Ruchi G. Marwah, Mike E. Deadman, Fathiya K. Al-Rawahi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


Phenylacetic acid derivatives, methyl 2-acetyl-3,5-dihydroxyphenylacetate (1) and methyl 2-acetyl-5-hydroxy-3-methoxyphenylacetate (3); curvulin or ethyl 2-acetyl-3,5-dihydroxyphenylacetate (4), a known metabolite of Curvularia siddiqui, and 4-epiradicinol (5) have been isolated from the culture mycelia of Curvularia lunata grown on YMG, a medium consisting of yeast, malt extract and glucose. Compounds 1, 3 and 4 lack antimicrobial and antioxidant activity, but 4-epiradicinol (5) inhibited the growth of Escherichia coli, Staphylococcus aureus, Salmonella choleraesuis and Bacillus subtilis. The structures of compounds 1, 3-5 were determined by analyses of IR, MS, 1D and 2D NMR data, assisted by chemical shift comparison to related and model compounds. The relative stereochemistry of the vicinal diol in 5 was determined from the 1H NMR signals for the methyl protons of the resulting cyclic acetonide prepared from 5.

Original languageEnglish
Pages (from-to)1925-1930
Number of pages6
Issue number17
Publication statusPublished - Sept 2006

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture


Dive into the research topics of 'Production of phenylacetic acid derivatives and 4-epiradicinol in culture by Curvularia lunata'. Together they form a unique fingerprint.

Cite this