TY - JOUR
T1 - Predictors of survival among patients with chronic hepatitis C at a tertiary care center in Oman
AU - Al-Shuaili, Halima H
AU - Al-Busafi, Said
AU - Al-Naamani, Khalid
AU - Al-Naamani, Zakariya
N1 - Publisher Copyright:
Copyright © 2023 Copyright: © 2023 Saudi Journal of Gastroenterology.
PY - 2024/1/1
Y1 - 2024/1/1
N2 - BACKGROUND: Chronic hepatitis C (CHC) is a leading cause of cirrhosis and hepatocellular carcinoma (HCC) worldwide. This study aimed to determine rates and predictors of survival among Omani patients with CHC at a tertiary hospital in Muscat, Oman.METHODS: This ambidirectional cohort study included all CHC patients who presented to the Sultan Qaboos University Hospital between January 2009 and December 2017. Baseline demographic, clinical, laboratory, and radiological data were analyzed. Patients were followed-up until death or the endpoint of the study (April 2022) to determine survival and associations with other parameters.RESULTS: A total of 702 CHC patients were included, of which 398 (56.7%) were under 50 years of age and 477 (67.9%) were male. Overall, 180 patients (25.6%) died by the study endpoint. The mean duration of follow-up was 93.3 ± 48.0 months. The 5-year survival rate was estimated to be 80.5%, while the 10-year survival was 73%. Sustained virological response and the absence of diabetes mellitus, chronic kidney disease, HCC, or other malignancies were associated with significantly better overall survival. The 3- and 5-year survival rate of patients with hepatitis C virus (HCV)-related HCC was 46.5% and 27.6%, respectively, with a median survival of 29.5 months. Co-infection with hepatitis B was associated with poor survival among this subgroup; conversely, early HCV screening and the presence of a single HCC lesion were associated with better overall survival.CONCLUSIONS: National policies for early CHC screening and rapid treatment are needed to improve survival rates in this population.
AB - BACKGROUND: Chronic hepatitis C (CHC) is a leading cause of cirrhosis and hepatocellular carcinoma (HCC) worldwide. This study aimed to determine rates and predictors of survival among Omani patients with CHC at a tertiary hospital in Muscat, Oman.METHODS: This ambidirectional cohort study included all CHC patients who presented to the Sultan Qaboos University Hospital between January 2009 and December 2017. Baseline demographic, clinical, laboratory, and radiological data were analyzed. Patients were followed-up until death or the endpoint of the study (April 2022) to determine survival and associations with other parameters.RESULTS: A total of 702 CHC patients were included, of which 398 (56.7%) were under 50 years of age and 477 (67.9%) were male. Overall, 180 patients (25.6%) died by the study endpoint. The mean duration of follow-up was 93.3 ± 48.0 months. The 5-year survival rate was estimated to be 80.5%, while the 10-year survival was 73%. Sustained virological response and the absence of diabetes mellitus, chronic kidney disease, HCC, or other malignancies were associated with significantly better overall survival. The 3- and 5-year survival rate of patients with hepatitis C virus (HCV)-related HCC was 46.5% and 27.6%, respectively, with a median survival of 29.5 months. Co-infection with hepatitis B was associated with poor survival among this subgroup; conversely, early HCV screening and the presence of a single HCC lesion were associated with better overall survival.CONCLUSIONS: National policies for early CHC screening and rapid treatment are needed to improve survival rates in this population.
KW - Humans
KW - Male
KW - Female
KW - Tertiary Care Centers
KW - Hepatitis C, Chronic/complications
KW - Oman/epidemiology
KW - Carcinoma, Hepatocellular/epidemiology
KW - Cohort Studies
KW - Liver Neoplasms/epidemiology
KW - screening
KW - liver cirrhosis
KW - Oman
KW - Chronic hepatitis C
KW - survival rate
KW - hepatocellular carcinoma
UR - http://www.scopus.com/inward/record.url?scp=85181992354&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85181992354&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/4a4b193f-2a8a-35ab-afde-ab20c99e10ca/
U2 - 10.4103/sjg.sjg_201_23
DO - 10.4103/sjg.sjg_201_23
M3 - Article
C2 - 38190454
SN - 1319-3767
VL - 30
SP - 45
EP - 52
JO - Saudi Journal of Gastroenterology
JF - Saudi Journal of Gastroenterology
IS - 1
ER -
