TY - JOUR
T1 - Predictors of Hypersensitivity Reactions to Platinum-Based Chemotherapy in a Tertiary Hospital in Oman
T2 - A case control study
AU - Salman, Bushra
AU - Al-Rasbi, Fatma
AU - Al-Ward, Nameer
AU - Al-Baimani, Khalid
AU - Burney, Ikram A.
AU - Abdullah, Eman
AU - Al-Azizi, Buthaina
AU - Al-Mishaikhi, Khulood
AU - Al-Zakwani, Ibrahim
AU - Al-Moundhri, Mansour
N1 - © Copyright 2023, Sultan Qaboos University Medical Journal, All Rights Reserved.
PY - 2023/5
Y1 - 2023/5
N2 - OBJECTIVES: This study aimed to estimate the prevalence and evaluate risk factors of hypersensitivity reactions (HSRs) to platinum-based compounds (PBCs) in cancer patients. PBCs play an important role in cancer therapy. However, one of the drawbacks of PBCs is the occasional occurrence of HSRs, which can lead to serious consequences.METHODS: This retrospective case control study was conducted from January 2013 to December 2020 at Sultan Qaboos University Hospital, Muscat, Oman and included patients who received any PBC for the management of non-haematological cancers. Data regarding demographic characteristics and diseases and treatment details were collected from the hospital's electronic database. The data were quantitatively described and Student's t-test and Wilcoxon Mann-Whitney tests were used to detect significant differences.RESULTS: A total of 38 cases and 148 matched controls were studied. The prevalence of HSRs to PBCs in the cohort of this study was 4.7% (95% confidence interval: 3.33-6.37%), higher with carboplatin compared with cisplatin and oxaliplatin. The female gender (
P = 0.032), concomitant taxanes (
P = 0.002) and concurrent radiation (
P <0.001) were significant predictors of HSRs to PBCs. The majority of the reactions were of mild to moderate severity, and the rechallenge rate after HSR development was 13%.
CONCLUSION: HSRs to PBCs impact therapy decisions and understanding the risk factors is important to improve treatment outcomes in cancer patients.
AB - OBJECTIVES: This study aimed to estimate the prevalence and evaluate risk factors of hypersensitivity reactions (HSRs) to platinum-based compounds (PBCs) in cancer patients. PBCs play an important role in cancer therapy. However, one of the drawbacks of PBCs is the occasional occurrence of HSRs, which can lead to serious consequences.METHODS: This retrospective case control study was conducted from January 2013 to December 2020 at Sultan Qaboos University Hospital, Muscat, Oman and included patients who received any PBC for the management of non-haematological cancers. Data regarding demographic characteristics and diseases and treatment details were collected from the hospital's electronic database. The data were quantitatively described and Student's t-test and Wilcoxon Mann-Whitney tests were used to detect significant differences.RESULTS: A total of 38 cases and 148 matched controls were studied. The prevalence of HSRs to PBCs in the cohort of this study was 4.7% (95% confidence interval: 3.33-6.37%), higher with carboplatin compared with cisplatin and oxaliplatin. The female gender (
P = 0.032), concomitant taxanes (
P = 0.002) and concurrent radiation (
P <0.001) were significant predictors of HSRs to PBCs. The majority of the reactions were of mild to moderate severity, and the rechallenge rate after HSR development was 13%.
CONCLUSION: HSRs to PBCs impact therapy decisions and understanding the risk factors is important to improve treatment outcomes in cancer patients.
KW - Anti-neoplastic Agent
KW - Hypersensitivity
KW - Medical Oncology
KW - Oman
KW - Platinum
KW - Tertiary Care Centers
KW - Humans
KW - Drug Hypersensitivity/epidemiology
KW - Hypersensitivity/complications
KW - Case-Control Studies
KW - Oman/epidemiology
KW - Female
KW - Retrospective Studies
KW - Platinum/adverse effects
UR - http://www.scopus.com/inward/record.url?scp=85162164577&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85162164577&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/45cf89a7-282e-36da-b5b6-2a755a0ced19/
U2 - 10.18295/squmj.1.2023.001
DO - 10.18295/squmj.1.2023.001
M3 - Article
C2 - 37377836
AN - SCOPUS:85162164577
SN - 2075-051X
VL - 23
SP - 233
EP - 238
JO - Sultan Qaboos University Medical Journal
JF - Sultan Qaboos University Medical Journal
IS - 2
ER -