Plasma vitamin C and tocotrienols changes in response to dietary supplementation among young male adults

Abdul Manaf Zahara, C. C. Lee, I. Siti Fatimah, B. K. Poh, O. Khairul, S. Das, J. Mohamad

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Background and Aims. Intake of the antioxidant vitamins C and E lowers the oxidative stress. The study aimed to determine plasma concentrations of vitamin C and tocotrienols after supplementation of both vitamins in young male adults. Materials and Methods. A total of 64 police recruits were randomly assigned to one of these groups: (a) 500 mg vitamin C (Vitamin C), (b) 200 mg Tocovid™(Tocotrienol), (c) combination of 500 mg vitamin C and 200 mg Tocovid™ (Combination) or (d) placebo (Placebo) for eight-weeks of supplementation followed by six-week washout period. Results. In Combination group, mean plasma vitamin C concentration significantly increased from baseline 2.86 ± 1.19 mg/L to 10.37 ± 1.29 mg/L and 15.63 ± 1.27 mg/L after four- and eight-week supplementation, respectively. The corresponding figures for α-, δ- and γ-tocotrienols were 9.9 ± 2.5 ng/ml to 104.1 ± 19.8 ng/ml and 112.8 ± 38.0 ng/ml; 2.5 ± 0.9 ng/ml to 29.9 ± 7.0 ng/ml and 17.9 ± 4.7 ng/ml; 19.2 ± 3.1 ng/ml to 75.2 ± 24.1 ng/ml and 161.7 ± 49.9 ng/ml, respectively. In Vitamin C group, plasma vitamin C concentrations were significantly increased. Conversely, concentration of plasma vitamin C in Tocotrienol group increased from baseline of 2.72 ± 0.20 mg/L to 6.80 ± 0.63 mg/L and 8.9 ± 0.77 mg/L respectively. Plasma concentrations of α-, δ- and γ-tocotrienols in this group were significantly elevated. After 6-week washout period, all the elevated concentrations returned to basal levels. Conclusion. The study showed a good bioavailability of these vitamins and increment due to supplementation.

Original languageEnglish
Pages (from-to)121-124
Number of pages4
JournalClinica Terapeutica
Issue number2
Publication statusPublished - 2010
Externally publishedYes


  • Antioxidant
  • Supplementation
  • Tocotrienols
  • Vitamin C
  • Young adults

ASJC Scopus subject areas

  • General Medicine


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