TY - JOUR
T1 - Phenotypic switching of vascular smooth muscle cells in atherosclerosis, hypertension, and aortic dissection
AU - Elmarasi, Mohamed
AU - Elmakaty, Ibrahim
AU - Elsayed, Basel
AU - Elsayed, Abdelrahman
AU - Zein, Jana Al
AU - Boudaka, Ammar
AU - Eid, Ali H.
N1 - Publisher Copyright:
© 2024 The Authors. Journal of Cellular Physiology published by Wiley Periodicals LLC.
PY - 2024/1/30
Y1 - 2024/1/30
N2 - Vascular smooth muscle cells (VSMCs) play a critical role in regulating vasotone, and their phenotypic plasticity is a key contributor to the pathogenesis of various vascular diseases. Two main VSMC phenotypes have been well described: contractile and synthetic. Contractile VSMCs are typically found in the tunica media of the vessel wall, and are responsible for regulating vascular tone and diameter. Synthetic VSMCs, on the other hand, are typically found in the tunica intima and adventitia, and are involved in vascular repair and remodeling. Switching between contractile and synthetic phenotypes occurs in response to various insults and stimuli, such as injury or inflammation, and this allows VSMCs to adapt to changing environmental cues and regulate vascular tone, growth, and repair. Furthermore, VSMCs can also switch to osteoblast-like and chondrocyte-like cell phenotypes, which may contribute to vascular calcification and other pathological processes like the formation of atherosclerotic plaques. This provides discusses the mechanisms that regulate VSMC phenotypic switching and its role in the development of vascular diseases. A better understanding of these processes is essential for the development of effective diagnostic and therapeutic strategies.
AB - Vascular smooth muscle cells (VSMCs) play a critical role in regulating vasotone, and their phenotypic plasticity is a key contributor to the pathogenesis of various vascular diseases. Two main VSMC phenotypes have been well described: contractile and synthetic. Contractile VSMCs are typically found in the tunica media of the vessel wall, and are responsible for regulating vascular tone and diameter. Synthetic VSMCs, on the other hand, are typically found in the tunica intima and adventitia, and are involved in vascular repair and remodeling. Switching between contractile and synthetic phenotypes occurs in response to various insults and stimuli, such as injury or inflammation, and this allows VSMCs to adapt to changing environmental cues and regulate vascular tone, growth, and repair. Furthermore, VSMCs can also switch to osteoblast-like and chondrocyte-like cell phenotypes, which may contribute to vascular calcification and other pathological processes like the formation of atherosclerotic plaques. This provides discusses the mechanisms that regulate VSMC phenotypic switching and its role in the development of vascular diseases. A better understanding of these processes is essential for the development of effective diagnostic and therapeutic strategies.
KW - aneurysm
KW - cardiovascular disease
KW - extracellular matrix
KW - migration
KW - theranostics
KW - Cell Proliferation
KW - Hypertension/pathology
KW - Humans
KW - Cells, Cultured
KW - Aortic Dissection
KW - Muscle, Smooth, Vascular/pathology
KW - Phenotype
KW - Myocytes, Smooth Muscle/pathology
KW - Atherosclerosis/pathology
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UR - https://www.mendeley.com/catalogue/0fe77a00-375f-3761-a596-c854d2bfbd75/
U2 - 10.1002/jcp.31200
DO - 10.1002/jcp.31200
M3 - Review article
C2 - 38291732
AN - SCOPUS:85183833224
SN - 0021-9541
VL - 239
JO - Journal of Cellular Physiology
JF - Journal of Cellular Physiology
IS - 4
M1 - e31200
ER -