TY - JOUR
T1 - Perspectives on the future of dysmorphology
AU - Solomon, Benjamin D.
AU - Adam, Margaret P.
AU - Fong, Chin To
AU - Girisha, Katta M.
AU - Hall, Judith G.
AU - Hurst, Anna C.E.
AU - Krawitz, Peter M.
AU - Moosa, Shahida
AU - Phadke, Shubha R.
AU - Tekendo-Ngongang, Cedrik
AU - Wenger, Tara L.
N1 - Publisher Copyright:
© 2022 Wiley Periodicals LLC. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.
PY - 2023/3
Y1 - 2023/3
N2 - The field of clinical genetics and genomics continues to evolve. In the past few decades, milestones like the initial sequencing of the human genome, dramatic changes in sequencing technologies, and the introduction of artificial intelligence, have upended the field and offered fascinating new insights. Though difficult to predict the precise paths the field will follow, rapid change may continue to be inevitable. Within genetics, the practice of dysmorphology, as defined by pioneering geneticist David W. Smith in the 1960s as “the study of, or general subject of abnormal development of tissue form” has also been affected by technological advances as well as more general trends in biomedicine. To address possibilities, potential, and perils regarding the future of dysmorphology, a group of clinical geneticists, representing different career stages, areas of focus, and geographic regions, have contributed to this piece by providing insights about how the practice of dysmorphology will develop over the next several decades.
AB - The field of clinical genetics and genomics continues to evolve. In the past few decades, milestones like the initial sequencing of the human genome, dramatic changes in sequencing technologies, and the introduction of artificial intelligence, have upended the field and offered fascinating new insights. Though difficult to predict the precise paths the field will follow, rapid change may continue to be inevitable. Within genetics, the practice of dysmorphology, as defined by pioneering geneticist David W. Smith in the 1960s as “the study of, or general subject of abnormal development of tissue form” has also been affected by technological advances as well as more general trends in biomedicine. To address possibilities, potential, and perils regarding the future of dysmorphology, a group of clinical geneticists, representing different career stages, areas of focus, and geographic regions, have contributed to this piece by providing insights about how the practice of dysmorphology will develop over the next several decades.
KW - dysmorphology
KW - medical genetics
KW - medical genomics
KW - Humans
KW - Artificial Intelligence
KW - Genomics
KW - Genome, Human
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U2 - 10.1002/ajmg.a.63060
DO - 10.1002/ajmg.a.63060
M3 - Article
C2 - 36484420
AN - SCOPUS:85144027874
SN - 1552-4825
VL - 191
SP - 659
EP - 671
JO - American Journal of Medical Genetics, Part A
JF - American Journal of Medical Genetics, Part A
IS - 3
ER -