Peripheral Demyelinating Diseases: From Biology to Translational Medicine

Khidhir Kamil, Muhammad Dain Yazid, Ruszymah Bt Hj Idrus, Srijit Das, Jaya Kumar*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

35 Citations (Scopus)


Demyelinating diseases represent a spectrum of disorders that impose significant burden on global economy and society. Generally, the prognosis of these diseases is poor and there is no available cure. In recent decades, research has shed some light on the biology and physiology of Schwann cells and its neuroprotective effects in the peripheral nervous system (PNS). Insults to the PNS by various infectious agents, genetic predisposition and immune-related mechanisms jeopardize Schwann cell functions and cause demyelination. To date, there are no effective and reliable biomarkers for PNS-related diseases. Here, we aim to review the following: pathogenesis of various types of peripheral demyelinating diseases such as Guillain-Barre syndrome, Chronic Inflammatory Demyelinating Polyradiculoneuropathy, Anti-Myelin Associated Glycoprotein Neuropathy, POEMS syndrome, and Charcot-Marie-Tooth disease; emerging novel biomarkers for peripheral demyelinating diseases, and Schwann cell associated markers for demyelination.

Original languageEnglish
Article number87
JournalFrontiers in Neurology
Publication statusPublished - Mar 19 2019


  • Charcot-Marie-Tooth disease
  • Guillain-Barre syndrome
  • POEMS syndrome
  • anti-MAG neuropathy
  • biomarker
  • chronic inflammatory demyelinating polyradiculoneuropathy
  • peripheral demyelinating disease
  • schwann cell

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


Dive into the research topics of 'Peripheral Demyelinating Diseases: From Biology to Translational Medicine'. Together they form a unique fingerprint.

Cite this