Pancreatic changes affecting glucose homeostasis in transfusion dependent β-thalassemia (TDT): A short review

Vincenzo de Sanctis; Ashraf T. Soliman; Ploutarchos Tzoulis; Shahina Daar; Bernadette Fiscina; Christos Kattamis

doi:10.23750/abm.v92i3.11685

Pancreatic changes affecting glucose homeostasis in transfusion dependent β-thalassemia (TDT): A short review

Vincenzo de Sanctis^*, Ashraf T. Soliman, Ploutarchos Tzoulis, Shahina Daar, Bernadette Fiscina, Christos Kattamis

^*Corresponding author for this work

Haematology

Research output: Contribution to journal › Review article › peer-review

10 Citations (Scopus)

Abstract

Background: The natural history of the glycometabolic state in transfusion-dependent β-thalassemia (TDT) patients is characterized by a deterioration of glucose tolerance over time. Aims: This review depicts our current knowledges on the complex and multifacet pathophysiologic mechanisms implicated in the development of alteration of glucose homeostasis in patients with TDT. Search strategy: A systematic search was done on December 2020 including Web of Science (ISI), Scopus, PubMed, Embase, and Scholar for papers published in the last 20 years. Moreover, we checked the reference lists of the relevant articles and previously performed reviews for additional pertinent studies. The personal experience on the care of patients with thalassemias is also reported. Conclusion: A regular packed red blood cells (PRBCs) transfusion program, optimization of chelation therapy, and prevention and treatment of liver infections are critical to achieve adequate glucometabolic control in TDT patients. Many exciting opportunities remain for further research and therapeutic development. (www.actabiomedica.it).

Original language	English
Article number	e2021232
Journal	Acta Biomedica
Volume	92
Issue number	3
DOIs	https://doi.org/10.23750/abm.v92i3.11685
Publication status	Published - Jul 1 2021

Keywords

Chronic liver disease
Diabetes mellitus
Insulin resistance
Iron overload
Thalassemia
Viral hepatitis

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.23750/abm.v92i3.11685

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title = "Pancreatic changes affecting glucose homeostasis in transfusion dependent β-thalassemia (TDT): A short review",

abstract = "Background: The natural history of the glycometabolic state in transfusion-dependent β-thalassemia (TDT) patients is characterized by a deterioration of glucose tolerance over time. Aims: This review depicts our current knowledges on the complex and multifacet pathophysiologic mechanisms implicated in the development of alteration of glucose homeostasis in patients with TDT. Search strategy: A systematic search was done on December 2020 including Web of Science (ISI), Scopus, PubMed, Embase, and Scholar for papers published in the last 20 years. Moreover, we checked the reference lists of the relevant articles and previously performed reviews for additional pertinent studies. The personal experience on the care of patients with thalassemias is also reported. Conclusion: A regular packed red blood cells (PRBCs) transfusion program, optimization of chelation therapy, and prevention and treatment of liver infections are critical to achieve adequate glucometabolic control in TDT patients. Many exciting opportunities remain for further research and therapeutic development. (www.actabiomedica.it).",

keywords = "Chronic liver disease, Diabetes mellitus, Insulin resistance, Iron overload, Thalassemia, Viral hepatitis",

author = "{de Sanctis}, Vincenzo and Soliman, {Ashraf T.} and Ploutarchos Tzoulis and Shahina Daar and Bernadette Fiscina and Christos Kattamis",

note = "Publisher Copyright: {\textcopyright} Mattioli 1885.",

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AU - Soliman, Ashraf T.

AU - Tzoulis, Ploutarchos

AU - Daar, Shahina

AU - Fiscina, Bernadette

AU - Kattamis, Christos

N1 - Publisher Copyright: © Mattioli 1885.

PY - 2021/7/1

Y1 - 2021/7/1

N2 - Background: The natural history of the glycometabolic state in transfusion-dependent β-thalassemia (TDT) patients is characterized by a deterioration of glucose tolerance over time. Aims: This review depicts our current knowledges on the complex and multifacet pathophysiologic mechanisms implicated in the development of alteration of glucose homeostasis in patients with TDT. Search strategy: A systematic search was done on December 2020 including Web of Science (ISI), Scopus, PubMed, Embase, and Scholar for papers published in the last 20 years. Moreover, we checked the reference lists of the relevant articles and previously performed reviews for additional pertinent studies. The personal experience on the care of patients with thalassemias is also reported. Conclusion: A regular packed red blood cells (PRBCs) transfusion program, optimization of chelation therapy, and prevention and treatment of liver infections are critical to achieve adequate glucometabolic control in TDT patients. Many exciting opportunities remain for further research and therapeutic development. (www.actabiomedica.it).

AB - Background: The natural history of the glycometabolic state in transfusion-dependent β-thalassemia (TDT) patients is characterized by a deterioration of glucose tolerance over time. Aims: This review depicts our current knowledges on the complex and multifacet pathophysiologic mechanisms implicated in the development of alteration of glucose homeostasis in patients with TDT. Search strategy: A systematic search was done on December 2020 including Web of Science (ISI), Scopus, PubMed, Embase, and Scholar for papers published in the last 20 years. Moreover, we checked the reference lists of the relevant articles and previously performed reviews for additional pertinent studies. The personal experience on the care of patients with thalassemias is also reported. Conclusion: A regular packed red blood cells (PRBCs) transfusion program, optimization of chelation therapy, and prevention and treatment of liver infections are critical to achieve adequate glucometabolic control in TDT patients. Many exciting opportunities remain for further research and therapeutic development. (www.actabiomedica.it).

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KW - Diabetes mellitus

KW - Insulin resistance

KW - Iron overload

KW - Thalassemia

KW - Viral hepatitis

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Pancreatic changes affecting glucose homeostasis in transfusion dependent β-thalassemia (TDT): A short review

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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